Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Henning, J"'
Autor:
Shreya Ghosh, Ana M. Sanchez, Beate Schwer, Isabel Prucker, Nikolaus Jork, Henning J. Jessen, Stewart Shuman
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Inositol pyrophosphate 1,5-IP8 regulates expression of a fission yeast phosphate homeostasis regulon, comprising phosphate acquisition genes pho1, pho84, and tgp1, via its action as an agonist of precocious termination of transcription of th
Externí odkaz:
https://doaj.org/article/5f61dc258abb4be5a6c4a2a0fa42b05e
Autor:
Hong Jiang, Martin Milanov, Gabriela Jüngert, Larissa Angebauer, Clara Flender, Eva Smudde, Fabian Gather, Tanja Vogel, Henning J. Jessen, Hans-Georg Koch
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110215- (2024)
Summary: The universally conserved YchF/Ola1 ATPases regulate stress response pathways in prokaryotes and eukaryotes. Deletion of YchF/Ola1 leads to increased resistance against environmental stressors, such as reactive oxygen species, while their up
Externí odkaz:
https://doaj.org/article/ad77c4f54f964b80ae1e6d30f1abff67
Autor:
Xingyao Li, Regan B. Kirkpatrick, Xiaodong Wang, Charles J. Tucker, Anuj Shukla, Henning J. Jessen, Huanchen Wang, Stephen B. Shears, Chunfang Gu
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114316- (2024)
Summary: Phosphate (Pi) serves countless metabolic pathways and is involved in macromolecule synthesis, energy storage, cellular signaling, and bone maintenance. Herein, we describe the coordination of Pi uptake and efflux pathways to maintain mammal
Externí odkaz:
https://doaj.org/article/f3b6e793e06f4a21a4aaa698b4a545cf
Autor:
Lisa Strotmann, Caroline Harter, Tatjana Gerasimova, Kevin Ritter, Henning J. Jessen, Daniel Wohlwend, Thorsten Friedrich
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract NADH:ubiquinone oxidoreductase, respiratory complex I, plays a major role in cellular energy metabolism by coupling electron transfer with proton translocation. Electron transfer is catalyzed by a flavin mononucleotide and a series of iron-s
Externí odkaz:
https://doaj.org/article/3647ff54d0fb47a6a4ba0d6b9b9dbcf2
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that conver
Externí odkaz:
https://doaj.org/article/f23c6334623f4c619e81c4cb2fd23874
Autor:
Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen, Andreas Mayer
Publikováno v:
eLife, Vol 12 (2023)
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway that utilize
Externí odkaz:
https://doaj.org/article/84ae01dea39c42028bb2abafbbccd1f1
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1278-1288 (2022)
Polyphosphate kinases (PPKs) have become popular biocatalysts for nucleotide 5'-triphosphate (NTP) synthesis and regeneration. Two unrelated families are described: PPK1 and PPK2. They are structurally unrelated and use different catalytic mechanisms
Externí odkaz:
https://doaj.org/article/ef97fa7dfa054971945ad63cb6f0a6b2
Autor:
Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter, Henning J. Jessen, Stephen B. Shears
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive m
Externí odkaz:
https://doaj.org/article/80727188fe0e4b42b9d3d714ec578029
Autor:
Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP8. IP8 dynamics are determined by Asp1, a bifunctional enzyme consisti
Externí odkaz:
https://doaj.org/article/05a2bc5f0397413b89f734e199a4c266
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1150 (2023)
Inositol phosphates constitute a family of highly charged messenger molecules that play diverse roles in cellular processes. The various phosphorylation patterns they exhibit give rise to a vast array of different compounds. To fully comprehend the b
Externí odkaz:
https://doaj.org/article/f9f021d79b9c4545b012152d578fea81