Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Eduardo Vilar"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMicrosatellite instability (MSI) secondary to mismatch repair (MMR) deficiency is characterized by insertions and deletions (indels) in short DNA sequences across the genome. These indels can generate neoantigens, which are ideal targets fo
Externí odkaz:
https://doaj.org/article/509da57fa7734bf1b9f4313ff32fed96
Autor:
EDUARDO VILAR BONALDI
Publikováno v:
Educação em Revista, Vol 39 (2023)
Externí odkaz:
https://doaj.org/article/aea367a81743487693a2489d994899cd
Autor:
Victoria Poplaski, Carolyn Bomidi, Amal Kambal, Hoa Nguyen-Phuc, Sara C. Di Rienzi, Heather A. Danhof, Xi-Lei Zeng, Linda A. Feagins, Nan Deng, Eduardo Vilar, Florencia McAllister, Cristian Coarfa, Soyoun Min, Hyun Jung Kim, Richa Shukla, Robert Britton, Mary K. Estes, Sarah E. Blutt
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Cronkhite-Canada Syndrome (CCS) is a rare, noninherited polyposis syndrome affecting 1 in every million individuals. Despite over 50 years of CCS cases, the etiopathogenesis and optimal treatment for CCS remains unknown due to the rarity of the disea
Externí odkaz:
https://doaj.org/article/7d873d427aea4ddf8d9a215681dfd7ad
Autor:
Asad Umar, Jack Lee, Diane Liu, Eduardo Vilar, Ellen Richmond, Powel H Brown, Laura Antonucci, Marcia Cruz-Correa, Michael J Hall, Guido Leoni, Gabriella Cotugno, Irene Garzia, Elisa Scarselli, Araceli Garcia-Gonzalez, Loredana Siani, Sven Gogov, Laura Reyes Uribe, Morena D’Alise, Jason Willis, Gregory E Idos, Lana A Vornik, Luz Maria Rodriguez
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/9928d0feba3a4df383ffe66a1290c95b
Autor:
Kathryn A. Mraz, Rachel Hodan, Linda Rodgers-Fouche, Sanjeevani Arora, Francesc Balaguer, Jose G. Guillem, Joanne M. Jeter, Priyanka Kanth, Dan Li, David Liska, Joshua Melson, Kimberly Perez, Charite Ricker, Brian H. Shirts, Eduardo Vilar, Bryson W. Katona, Mev Dominguez-Valentin
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundInternational chemoprevention preferences and approaches in Lynch syndrome (LS) and APC-associated polyposis, including Familial adenomatous polyposis (FAP) and attenuated FAP (AFAP) have not been previously explored.AimTo describe current
Externí odkaz:
https://doaj.org/article/749d660edbd94ab487e05ec3dcad75d6
Autor:
Charles M. Bowen, Nan Deng, Laura Reyes-Uribe, Edwin Roger Parra, Pedro Rocha, Luisa M. Solis, Ignacio I. Wistuba, Valerie O. Sepeda, Lana Vornik, Marjorie Perloff, Eva Szabo, Asad Umar, Krishna M. Sinha, Powel H. Brown, Eduardo Vilar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundRecent clinical trial data from Lynch Syndrome (LS) carriers demonstrated that naproxen administered for 6-months is a safe primary chemoprevention that promotes activation of different resident immune cell types without increasing lymphoid
Externí odkaz:
https://doaj.org/article/3d55b651927345eea41865d744b4c4c0
Autor:
Gabriel del Carmen, Laura Reyes-Uribe, Daniel Goyco, Kyera Evans, Charles M. Bowen, Jennifer L. Kinnison, Valerie O. Sepeda, Diane M. Weber, Julie Moskowitz, Maureen E. Mork, Selvi Thirumurthi, Patrick M. Lynch, Miguel A. Rodriguez-Bigas, Melissa W. Taggart, Y. Nancy You, Eduardo Vilar
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectiveLynch Syndrome (LS) carriers have a significantly increased risk of developing colorectal cancer (CRC) during their lifetimes. Further stratification of this patient population may help in identifying additional risk factors that predispose
Externí odkaz:
https://doaj.org/article/f5b17bbf15784d4dbbd400cc8d3e166e
Autor:
Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathiotis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Deregulation of the BCL-2 family interactions ensures cancer resistance to apoptosis and is a major challenge to current treatments. Here the authors describe a novel therapeutic strategy to overcome two anti-apoptotic mechanisms for cancer therapy.
Externí odkaz:
https://doaj.org/article/5fa5a69a971e4641aa8580f63eda1948
Autor:
Shaoheng Liang, Jason Willis, Jinzhuang Dou, Vakul Mohanty, Yuefan Huang, Eduardo Vilar, Ken Chen
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Cellular heterogeneity underlies cancer evolution and metastasis. Advances in single-cell technologies such as single-cell RNA sequencing and mass cytometry have enabled interrogation of cell type-specific expression profiles and abundance a
Externí odkaz:
https://doaj.org/article/4fcb4da3ef4c4e049e0fa8fffd70138d
Autor:
Ignacio I Wistuba, Andrew Futreal, Xuemei Wang, Arvind Dasari, Cathy Eng, Scott Kopetz, Edwin R Parra, Cara L Haymaker, Eduardo Vilar, Robert A Wolff, Kanwal Raghav, Michael J Overman, Younghee Lee, Benny Johnson, Luisa Maren Solis Soto, Jane V Thomas, Van K Morris, Bryan K Kee, Christine M Parseghian, Daniele Lorenzini, Caddie Laberiano-Fernandez, Anuj Verma, Wenhua Lang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background Monotherapy with immune checkpoint blockade is ineffective for patients (pts) with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). This study investigates whether the combination of trametinib (T) with durvalumab (D) can a
Externí odkaz:
https://doaj.org/article/df046ec2d0ff48c99275fc303b6ac56b