Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donald M. Small"'
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 840-852 (2017)
Plasma apoC-III levels correlate with triglyceride (TG) levels and are a strong predictor of CVD outcomes. ApoC-III elevates TG in part by inhibiting LPL. ApoC-III likely inhibits LPL by competing for lipid binding. To probe this, we used oil-drop te
Externí odkaz:
https://doaj.org/article/c5c15204a798475c9c144f183802cfac
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 478-492 (2014)
Apolipoprotein A-I (apoA-I) has a great conformational flexibility to exist in lipid-free, lipid-poor, and lipid-bound states during lipid metabolism. To address the lipid binding and the dynamic desorption behavior of apoA-I at lipoprotein surfaces,
Externí odkaz:
https://doaj.org/article/f511436172f8403faf6b92e58ef21a46
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1927-1938 (2013)
Amphipathic α-helices mediate binding of exchangeable apolipoproteins to lipoproteins. To probe the role of α-helical structure in protein-lipid interactions, we used oil-drop tensiometry to characterize the interfacial behavior of apolipoprotein C
Externí odkaz:
https://doaj.org/article/92929ec14ead4fcdb33bb93b4f766dd1
Autor:
Matthew A. Mitsche, Donald M. Small
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1578-1588 (2013)
Amphipathic α-helices (AαH) are the primary structural motif of exchangeable apolipoproteins. AαHs in exchangeable apolipoproteins adsorb, remodel, and desorb at the surface of plasma lipoproteins in response to changes in their size or compositio
Externí odkaz:
https://doaj.org/article/d63d507121724d2c935f10da0d3b0b27
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 7, Pp 1340-1352 (2009)
Apolipoprotein B (apoB) is a nonexchangeable apolipoprotein. During lipoprotein assembly, it recruits phospholipids and triacylglycerols (TAG) into TAG-rich lipoprotein particles. It remains bound to secreted lipoproteins during lipid metabolism in p
Externí odkaz:
https://doaj.org/article/0b4faf0ffb52493288094db49aaefa35
Autor:
Libo Wang, Donald M. Small
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 9, Pp 1704-1715 (2004)
The region between residues 968 and 1882 of apolipoprotein B (apoB-21 to apoB-41) is rich in amphipathic β strands (AβSs) and promotes the assembly of primordial triacylglyceride (TAG)-rich lipoproteins. To understand the importance of AβS in recr
Externí odkaz:
https://doaj.org/article/4a62788fd1f5455788865c8051d4083a
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 3, Pp 338-345 (2001)
The crystal structure of the β′-2 form of a mixed chain triacylglycerol (TAG), 1,2-dipalmitoyl-3-myristoyl-sn-glycerol (PPM), was determined to a final reliability factor of 0.074. This work is the first to resolve the atomic-level structure of th
Externí odkaz:
https://doaj.org/article/8a6a93c0e5cb48fa82b813571c25939c
Autor:
Haya Herscovitz, Arie Derksen, Mary T. Walsh, C. James McKnight, Donald L. Gantz, Margarita Hadzopoulou-Cladaras, Vassilis Zannis, Cynthia Curry, Donald M. Small
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 1, Pp 51-59 (2001)
The N-terminal 17% of apolipoprotein B (apoB-17) readily associates with dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV) to form large (240-Å diameter) discoidal particles. Because apoB is normally secreted with triacylglycerol (T
Externí odkaz:
https://doaj.org/article/569b49412d394a5fa1d7e918a03e0ce9
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 9, Pp 1464-1472 (2000)
The primary and secondary structures of apolipoprotein B-100 (apoB-100) are well established. Previous morphological studies have suggested that apoB is a long, flexible, threadlike molecule that encircles the low density lipoprotein (LDL) particle.
Externí odkaz:
https://doaj.org/article/418e108dbd4e4e139cf1ad8f3f89b7ce
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 1, Pp 140-151 (1999)
Polymorphic transformations in two saturated-unsaturated mixed acid triacylglycerols, SOS (sn-1,3-distearoyl-2-oleoylglycerol) and OSO (sn-1,3-dioleoyl-2-stearoylglycerol), have been studied by FT-IR spectroscopy using deuterated specimens in which s
Externí odkaz:
https://doaj.org/article/999cb4aa248044bbb68b6b1e8ca91518