Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Daisuke Ogasawara"'
Autor:
Zhen Chen, Wakana Mori, Jian Rong, Michael A. Schafroth, Tuo Shao, Richard S. Van, Daisuke Ogasawara, Tomoteru Yamasaki, Atsuto Hiraishi, Akiko Hatori, Jiahui Chen, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Jiyun Sun, Qingzhen Yu, Thomas L. Collier, Yihan Shao, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1686-1695 (2021)
As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been
Externí odkaz:
https://doaj.org/article/6647b3af1e7f460aab63220f173d99be
Publikováno v:
Applied Sciences, Vol 13, Iss 1, p 444 (2022)
We have developed a supersonic pulsed plasma jet device capable of long-distance and high-speed processing, and investigated its basic characteristics for surface treatment applications, mainly in the material and medical fields. The developed appara
Externí odkaz:
https://doaj.org/article/0a1c9c7ad7944ab6874a98050ac10a7f
SYNTHESIS, LSD1 INHIBITORY ACTIVITY, AND LSD1 BINDING MODEL OF OPTICALLY PURE LYSINE-PCPA CONJUGATES
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 9, Iss 14, Pp 1-9 (2014)
Compounds that inhibit the catalytic function of lysine-specific demethylase 1 (LSD1) are interesting as therapeutic agents. Recently, we identified three lysine-phenylcyclopropylamine conjugates, NCD18, NCD25, and NCD41, which are potent LSD1 inacti
Externí odkaz:
https://doaj.org/article/c0ac128d1d6f4d0e8b8810054bdd5f51
Autor:
Andreu Viader, Daisuke Ogasawara, Christopher M Joslyn, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Benjamin F Cravatt
Publikováno v:
eLife, Vol 5 (2016)
Metabolic specialization among major brain cell types is central to nervous system function and determined in large part by the cellular distribution of enzymes. Serine hydrolases are a diverse enzyme class that plays fundamental roles in CNS metabol
Externí odkaz:
https://doaj.org/article/d5e645537bb8498db55da5346fdc087b