Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christopher L.-H. Huang"'
Autor:
Federico Bertagna, Shiraz Ahmad, Rebecca Lewis, S. Ravi P. Silva, Johnjoe McFadden, Christopher L.-H. Huang, Hugh R. Matthews, Kamalan Jeevaratnam
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionThe loose-patch clamp technique was first developed and used in native amphibian skeletal muscle (SkM), offering useful features complementing conventional sharp micro-electrode, gap, or conventional patch voltage clamping. It demonstrate
Externí odkaz:
https://doaj.org/article/94e8beade09943b6a18bc501602977b3
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Cardiac arrhythmias cause significant morbidity and mortality and pose a major public health problem. They arise from disruptions in the normally orderly propagation of cardiac electrophysiological activation and recovery through successive cardiomyo
Externí odkaz:
https://doaj.org/article/5931e0cf47424e51a948af6be9c4a03b
Autor:
Ying H. Huang, MMath, PhD, Jane V. Lyle, BSc, Anisa Shahira Ab Razak, BA, Manasi Nandi, BSc, PhD, Celia M. Marr, BVMS, MVM, PhD, DEIM, DipECEIM, FRCVS, Christopher L.-H. Huang, BA, BM, BCh, PhD, DM, MD, DSc, ScD, FRSB, Philip J. Aston, BSc, PhD, Kamalan Jeevaratnam, DAHP, DVM, MMedSC, PhD, FRCVS
Publikováno v:
Cardiovascular Digital Health Journal, Vol 3, Iss 2, Pp 96-106 (2022)
Background: Atrial fibrillation (AF) is a common cardiac arrhythmia in both human and equine populations. It is associated with adverse outcomes in humans and decreased athletic performance in both populations. Paroxysmal atrial fibrillation (PAF) pr
Externí odkaz:
https://doaj.org/article/8f50d0217e2343dcae7574277cb04b72
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract A finite element analysis modelled diffusional generation of steady-state Ca2+ microdomains within skeletal muscle transverse (T)-tubular-sarcoplasmic reticular (SR) junctions, sites of ryanodine receptor (RyR)-mediated SR Ca2+ release. It u
Externí odkaz:
https://doaj.org/article/48d31e6e90444a8f8b311e1a53fd6e0a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (I Na) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffei
Externí odkaz:
https://doaj.org/article/6f44123619ea4ddabbb1ac1ad20bffe5
Autor:
Esther Bonet-Luz, MMath, PhD, Jane V. Lyle, BSc, Christopher L.-H. Huang, MA, BMBCh, DM, DSc, PhD, MD, ScD, Yanmin Zhang, MD, PhD, Manasi Nandi, BSc, PhD, Kamalan Jeevaratnam, DAHP, DVM, MMedSC, PhD, MRCVS, Philip J. Aston, BSc, PhD
Publikováno v:
Heart Rhythm O2, Vol 1, Iss 5, Pp 368-375 (2020)
Background: Life-threatening arrhythmias resulting from genetic mutations are often missed in current electrocardiogram (ECG) analysis. We combined a new method for ECG analysis that uses all the waveform data with machine learning to improve detecti
Externí odkaz:
https://doaj.org/article/fce511eb313c4fd4a215e909aeff36ca
Autor:
Christopher A. Beaudoin, Samir W. Hamaia, Christopher L.-H. Huang, Tom L. Blundell, Antony P. Jackson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both o
Externí odkaz:
https://doaj.org/article/6232723385df46bc893a5afb2e3780ce
Transcriptional profiles of genes related to electrophysiological function in Scn5a+/− murine hearts
Autor:
Michael Takla, Charlotte E. Edling, Kevin Zhang, Khalil Saadeh, Gary Tse, Samantha C. Salvage, Christopher L.‐H. Huang, Kamalan Jeevaratnam
Publikováno v:
Physiological Reports, Vol 9, Iss 19, Pp n/a-n/a (2021)
Abstract The Scn5a gene encodes the major pore‐forming Nav1.5 (α) subunit, of the voltage‐gated Na+ channel in cardiomyocytes. The key role of Nav1.5 in action potential initiation and propagation in both atria and ventricles predisposes organis
Externí odkaz:
https://doaj.org/article/edef003b381440f3af65dbd7393d25d6
Autor:
Tiangang Zhu, Ming Lei, Zhilong Wang, Rongli Zhang, Yan Zhang, Wenying Jin, Chao Yu, Christopher L.-H. Huang, Dongyue Liu, Wen Zheng, Yuli Liu, Xin Quan, Lingyun Kong, Siying Liang, Xiuqin Zhang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Aim: Mechanical dyssynchrony (MD) is associated with heart failure (HF) and may be prognostically important in cardiac resynchronization therapy (CRT). Yet, little is known about its patterns in healthy or diseased hearts. We here investigate and com
Externí odkaz:
https://doaj.org/article/619a87fb140f41628fc45ce6e9e52472
Autor:
Khalil Saadeh, Karan R. Chadda, Shiraz Ahmad, Haseeb Valli, Nakulan Nanthakumar, Ibrahim T. Fazmin, Charlotte E. Edling, Christopher L.-H. Huang, Kamalan Jeevaratnam
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 27, Iss , Pp 100753- (2021)
Mitochondrial dysfunction underlying metabolic disorders such as obesity and diabetes mellitus is strongly associated with cardiac arrhythmias. Murine Pgc-1α−/− hearts replicate disrupted mitochondrial function and model the associated pro-arrhy
Externí odkaz:
https://doaj.org/article/5b3313281d784c3081ca659d1886a157