Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brodesser, A."'
Autor:
Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N. Melo, Ana J. García-Sáez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis execution. However, the molecular architecture of the mitochondrial apoptotic pore
Externí odkaz:
https://doaj.org/article/2bee97a155664393b38bf835ce663f24
Autor:
Philipp Hammerschmidt, Sophie M. Steculorum, Cécile L. Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F. U. Klar, Corinna A. Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L. Horvath, Thorsten Hornemann, Susanne Brodesser, Jens C. Brüning
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscur
Externí odkaz:
https://doaj.org/article/0ef32131373a4665897de31f813f7c3c
Autor:
Daniela M. Brodesser, Stefan Kummer, Julia A. Eichberger, Karin Schlangen, Annunziata Corteggio, Giuseppe Borzacchiello, Christof A. Bertram, Sabine Brandt, Barbara Pratscher
Publikováno v:
Cells, Vol 13, Iss 11, p 956 (2024)
The ability of human melanoma cells to switch from an epithelial to a mesenchymal phenotype contributes to the metastatic potential of disease. Metalloproteinases (MPs) are crucially involved in this process by promoting the detachment of tumor cells
Externí odkaz:
https://doaj.org/article/40b906e5eaad4f8a95e1ce8cb9095d5f
Autor:
Maithily S. Nanadikar, Ana M. Vergel Leon, Jia Guo, Gijsbert J. van Belle, Aline Jatho, Elvina S. Philip, Astrid F. Brandner, Rainer A. Böckmann, Runzhu Shi, Anke Zieseniss, Carla M. Siemssen, Katja Dettmer, Susanne Brodesser, Marlen Schmidtendorf, Jingyun Lee, Hanzhi Wu, Cristina M. Furdui, Sören Brandenburg, Joseph R. Burgoyne, Ivan Bogeski, Jan Riemer, Arpita Chowdhury, Peter Rehling, Tobias Bruegmann, Vsevolod V. Belousov, Dörthe M. Katschinski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, w
Externí odkaz:
https://doaj.org/article/46b0dc091943496094992a4e0a96de5f
Autor:
Reimer, Nadine, Brodesser, Dirk, Ratiu, Dominik, Zubac, Damir, Lehmann, Helmar C., Baumann, Freerk T.
Publikováno v:
GMS German Medical Science, Vol 21, p Doc08 (2023)
Introduction: Peripheral neuropathy (PNP) in feet and/or hands and sexual dysfunction are common side effects of cancer therapies. In patients with other diseases, there is evidence of an association between peripheral nervous system disorders and se
Externí odkaz:
https://doaj.org/article/7d8ca3538c4840609e5b71970d26861d
Publikováno v:
Animals, Vol 13, Iss 9, p 1575 (2023)
Employing living animals in educational settings is popular and may assist learning. Human-animal relationships are considered fundamental for the effects of animal-assisted interventions (AAI) on successful learning. Key studies on AAI emphasize dog
Externí odkaz:
https://doaj.org/article/5832904fed1f446d89e86a593e17294b
Autor:
Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt, Silvia von Karstedt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vul
Externí odkaz:
https://doaj.org/article/72d102a3804747f8993f740dde35ff92
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101335- (2021)
Objective: An increased ω6/ω3-polyunsaturated fatty acid ratio in the current Western diet is regarded as a critical epigenetic nutritional factor in the pathogenesis of several human lifestyle diseases, metabolic syndrome, cardiovascular disease,
Externí odkaz:
https://doaj.org/article/0ab0a8646fc246a4be0c3cb1177626a4
Autor:
L. M. Schiffmann, J. P. Werthenbach, F. Heintges-Kleinhofer, J. M. Seeger, M. Fritsch, S. D. Günther, S. Willenborg, S. Brodesser, C. Lucas, C. Jüngst, M. C. Albert, F. Schorn, A. Witt, C. T. Moraes, C. J. Bruns, M. Pasparakis, M. Krönke, S. A. Eming, O. Coutelle, H. Kashkar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
During angiogenesis the vasculature switches from a quiescent to a proliferative state. Here the authors show that mitochondrial respiration in endothelial cells controls angiogenesis during development, tumour growth and tissue repair.
Externí odkaz:
https://doaj.org/article/4c6615fd88894f849a3f974b6b81f021
Autor:
Edmund K. Hainisch, Christoph Jindra, Paul Reicher, Lea Miglinci, Daniela M. Brodesser, Sabine Brandt
Publikováno v:
Viruses, Vol 14, Iss 12, p 2658 (2022)
Equine sarcoids are common, locally aggressive skin tumors induced by bovine papillomavirus types 1, 2, and possibly 13 (BPV1, BPV2, BPV13). Current in vitro models do not mimic de novo infection. We established primary fibroblasts from horse skin an
Externí odkaz:
https://doaj.org/article/c9419d57bbb9460a9ba510c80f7563b6