Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Andreas Villunger"'
Autor:
Michael Lohmüller, Bernhard F. Roeck, Tamas G. Szabo, Marina A. Schapfl, Fragka Pegka, Sebastian Herzog, Andreas Villunger, Fabian Schuler
Publikováno v:
Molecular Oncology, Vol 16, Iss 15, Pp 2771-2787 (2022)
Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of under‐replicated DNA or exogenous DNA damage. Cancer cells deficient in p53 tumor suppressor func
Externí odkaz:
https://doaj.org/article/813987d97eda4623b0c6dc51025a7d5f
Autor:
Gerlinde Karbon, Manuel D. Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl, Andreas Villunger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Abstract Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mi
Externí odkaz:
https://doaj.org/article/be72c07d709a45b1826c65c6dd5e8661
Autor:
Katharina Hutter, Thomas Rülicke, Tamas G. Szabo, Lill Andersen, Andreas Villunger, Sebastian Herzog
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
MicroRNAs are small non-coding RNAs that have emerged as post-transcriptional regulators involved in development and function of different types of immune cells, and aberrant miRNA expression has often been linked to cancer. One prominent miRNA famil
Externí odkaz:
https://doaj.org/article/d7203d1cea344819b421c719e24a2b13
Autor:
Taimoor I. Sheikh, Nasim Vasli, Stephen Pastore, Kimia Kharizi, Ricardo Harripaul, Zohreh Fattahi, Shruti Pande, Farooq Naeem, Abrar Hussain, Asif Mir, Omar Islam, Katta Mohan Girisha, Muhammad Irfan, Muhammad Ayub, Christoph Schwarzer, Hossein Najmabadi, Anju Shukla, Valentina C. Sladky, Vincent Zoran Braun, Irmina Garcia-Carpio, Andreas Villunger, John B. Vincent
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract PIDD1 encodes p53-Induced Death Domain protein 1, which acts as a sensor surveilling centrosome numbers and p53 activity in mammalian cells. Early results also suggest a role in DNA damage response where PIDD1 may act as a cell-fate switch,
Externí odkaz:
https://doaj.org/article/59946732b5df4eecace75327ea1e1e2b
Autor:
Leonie Meyer-Heemsoth, Katja Mitschke, Jasmina Bier, Konstantin Schütz, Andreas Villunger, Tobias J. Legler, Martin S. Weber, Fred Lühder, Holger M. Reichardt
Publikováno v:
Cells, Vol 12, Iss 3, p 450 (2023)
Glucocorticoids (GCs) are used to treat inflammatory disorders such as multiple sclerosis (MS) by exerting prominent activities in T cells including apoptosis induction and suppression of cytokine production. However, little is known about their impa
Externí odkaz:
https://doaj.org/article/7aa68e66f5924d57a5e3dda753c2a6fd
Publikováno v:
Cancers, Vol 15, Iss 1, p 30 (2022)
Aneuploidy is the gain or loss of entire chromosomes, chromosome arms or fragments. Over 100 years ago, aneuploidy was described to be a feature of cancer and is now known to be present in 68–90% of malignancies. Aneuploidy promotes cancer growth,
Externí odkaz:
https://doaj.org/article/a9d12048709d49a0a183de045f4775ae
Publikováno v:
Cells, Vol 11, Iss 14, p 2126 (2022)
Glucocorticoids (GC) are highly potent negative regulators of immune and inflammatory responses. Effects of GC are primarily mediated by the glucocorticoid receptor (GR) which is expressed by all cell types of the immune system. It is, therefore, dif
Externí odkaz:
https://doaj.org/article/0e4f270e9c844f80bc80b0b14480c01a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10883 (2021)
P53 is known as the most critical tumor suppressor and is often referred to as the guardian of our genome. More than 40 years after its discovery, we are still struggling to understand all molecular details on how this transcription factor prevents o
Externí odkaz:
https://doaj.org/article/66a5b6fecd0041288c290f2bbaf10938
Autor:
Fabian Schuler, Johannes G. Weiss, Silke E. Lindner, Michael Lohmüller, Sebastian Herzog, Simon F. Spiegl, Philipp Menke, Stephan Geley, Verena Labi, Andreas Villunger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell surv
Externí odkaz:
https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09
Autor:
Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J. Herold, Andreas Strasser, Andreas Villunger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tet-transactivators are used for direct regulation of gene expression, RNA interference and for CRISPR/Cas9-based systems. Here the authors show that DNA-bound Tet-transactivators can induce cell death in antigen-activated lymphocytes in vivo, puttin
Externí odkaz:
https://doaj.org/article/28a3c17a5020441bb28ab5bc1d8548fa