Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jiri Bartek"'
Autor:
Kang Wang, Ioannis Zerdes, Henrik J. Johansson, Dhifaf Sarhan, Yizhe Sun, Dimitris C. Kanellis, Emmanouil G. Sifakis, Artur Mezheyeuski, Xingrong Liu, Niklas Loman, Ingrid Hedenfalk, Jonas Bergh, Jiri Bartek, Thomas Hatschek, Janne Lehtiö, Alexios Matikas, Theodoros Foukakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Although metabolic reprogramming within tumor cells and tumor microenvironment (TME) is well described in breast cancer, little is known about how the interplay of immune state and cancer metabolism evolves during treatment. Here, we charact
Externí odkaz:
https://doaj.org/article/b1fcc99c167b4d128ce9d55c41851b89
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
RNA has been implicated in DNA repair. This work shows that the interplay of RNAPII-generated nascent RNA, RNA:DNA hybrids and the resection factor CtIP guide DNA double strand break repair pathway choice towards error-free homologous recombination.
Externí odkaz:
https://doaj.org/article/2767a422a100492a835b400bd99be8cf
Autor:
Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Emanuele Martini, Umberto Restuccia, Miguel Angel Ramirez-Otero, Massimiliano Garre, Eleonora Verga, Miguel Andújar-Sánchez, Scott Maynard, Zdenek Hodny, Vincenzo Costanzo, Amit Kumar, Angela Bachi, Andrés Aguilera, Jiri Bartek, Marco Foiani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication str
Externí odkaz:
https://doaj.org/article/18fbf66c3f8442a6835b1d14c7f9ffa2
Autor:
Martin Mistrik, Zdenek Skrott, Petr Muller, Ales Panacek, Lucie Hochvaldova, Katarina Chroma, Tereza Buchtova, Veronika Vandova, Libor Kvitek, Jiri Bartek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Existing methods for inflicting cellular heat shock are limited by the time delay in achieving the desired temperature and the spatial precision that can be achieved. Here the authors report a method to induce focused thermal protein damage using pla
Externí odkaz:
https://doaj.org/article/67d69097392d41a296cc051f0474624c
Autor:
Elisabeth Anne Adanma Obara, Diana Aguilar-Morante, Rikke Darling Rasmussen, Alex Frias, Kristoffer Vitting-Serup, Yi Chieh Lim, Kirstine Juul Elbæk, Henriette Pedersen, Lina Vardouli, Kamilla Ellermann Jensen, Jane Skjoth-Rasmussen, Jannick Brennum, Lucie Tuckova, Robert Strauss, Christoffel Dinant, Jiri Bartek, Petra Hamerlik
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA rep
Externí odkaz:
https://doaj.org/article/e023985afb8f4badb8ede0a95ade1510
Autor:
Gururaj Rao Kidiyoor, Qingsen Li, Giulia Bastianello, Christopher Bruhn, Irene Giovannetti, Adhil Mohamood, Galina V. Beznoussenko, Alexandre Mironov, Matthew Raab, Matthieu Piel, Umberto Restuccia, Vittoria Matafora, Angela Bachi, Sara Barozzi, Dario Parazzoli, Emanuela Frittoli, Andrea Palamidessi, Tito Panciera, Stefano Piccolo, Giorgio Scita, Paolo Maiuri, Kristina M. Havas, Zhong-Wei Zhou, Amit Kumar, Jiri Bartek, Zhao-Qi Wang, Marco Foiani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and
Externí odkaz:
https://doaj.org/article/ef3b7523ea5c4ef99f9147b73d2702d2
Autor:
Asgeir Store Jakola, Katja Werlenius, Munila Mudaisi, Sofia Hylin, Sara Kinhult, Jiri Bartek Jr., Øyvind Salvesen, Sven Magnus Carlsen, Michael Strandéus, Magnus Lindskog, David Löfgren, Bertil Rydenhag, Louise Carstam, Sasha Gulati, Ole Solheim, Jiri Bartek, Tora Solheim
Publikováno v:
F1000Research, Vol 7 (2018)
Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and experimental data suggest th
Externí odkaz:
https://doaj.org/article/304c17d0cae74f89a04c6ab97b80e8a7
Autor:
Rikke D. Rasmussen, Madhavsai K. Gajjar, Lucie Tuckova, Kamilla E. Jensen, Apolinar Maya-Mendoza, Camilla B. Holst, Kjeld Møllgaard, Jane S. Rasmussen, Jannick Brennum, Jiri Bartek, Martin Syrucek, Eva Sedlakova, Klaus K. Andersen, Marie H. Frederiksen, Petra Hamerlik
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication str
Externí odkaz:
https://doaj.org/article/6430b3d745974eb39d5f81ae0bb6be25
Autor:
Ana López-Saavedra, Daniel Gómez-Cabello, María Salud Domínguez-Sánchez, Fernando Mejías-Navarro, María Jesús Fernández-Ávila, Christoffel Dinant, María Isabel Martínez-Macías, Jiri Bartek, Pablo Huertas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end rese
Externí odkaz:
https://doaj.org/article/1d49ffd398a147089d057cbfe5d89dfe
Autor:
Alexander Fletcher-Sandersjöö, Eric Peter Thelin, Jiri Bartek, Adrian Elmi-Terander, Mikael Broman, Bo-Michael Bellander
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190365 (2017)
Intracranial hemorrhage (ICH) is a common complication in adults treated with extracorporeal membrane oxygenation (ECMO). The aim of this study was to identify predictors of outcome and investigate intervention strategies following ICH development in
Externí odkaz:
https://doaj.org/article/4b361998758b4238819ba8977b02e037