Zobrazeno 1 - 10
of 51
pro vyhledávání: '"521"'
Autor:
Antonella Turchiano, Marilidia Piglionica, Stefania Martino, Rosanna Bagnulo, Antonella Garganese, Annunziata De Luisi, Stefania Chirulli, Matteo Iacoviello, Michele Stasi, Ornella Tabaku, Eleonora Meneleo, Martina Capurso, Silvia Crocetta, Simone Lattarulo, Yevheniia Krylovska, Patrizia Lastella, Cinzia Forleo, Alessandro Stella, Nenad Bukvic, Cristiano Simone, Nicoletta Resta
Publikováno v:
Genes, Vol 14, Iss 8, p 1530 (2023)
Breast cancer (BC) is the most common cancer and the leading cause of cancer death in women worldwide. Since the discovery of the highly penetrant susceptibility genes BRCA1 and BRCA2, many other predisposition genes that confer a moderate risk of BC
Externí odkaz:
https://doaj.org/article/d062736c3c07428fbfe92390d0b9f52e
Autor:
Courtney E. French, Helen Dolling, Karyn Mégy, Alba Sanchis-Juan, Ajay Kumar, Isabelle Delon, Matthew Wakeling, Lucy Mallin, Shruti Agrawal, Topun Austin, Florence Walston, Soo-Mi Park, Alasdair Parker, Chinthika Piyasena, Kimberley Bradbury, Sian Ellard, David H. Rowitch, F. Lucy Raymond
Publikováno v:
HGG Advances, Vol 3, Iss 3, Pp 100113- (2022)
Summary: To facilitate early deployment of whole-genome sequencing (WGS) for severely ill children, a standardized pipeline for WGS analysis with timely turnaround and primary care pediatric uptake is needed. We developed a bioinformatics pipeline fo
Externí odkaz:
https://doaj.org/article/d0639a514d104d5591320431e35ee69b
Autor:
Yunsheng Ge, Jiayan Chen, Yanru Huang, Di Shao, Wenbo Wang, Meijiao Cai, Meihua Tan, Jian Zhang
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Fetal chromosomal abnormalities are the main cause of adverse pregnancy outcomes and are the focus of invasive prenatal diagnosis. Recent studies have demonstrated that various techniques have distinct advantages. Achieving high-resolution and effect
Externí odkaz:
https://doaj.org/article/81aee62e5a1c4754b05a2e0eb128a48f
Autor:
Michael Rade, Sebastian Böhlen, Vanessa Neuhaus, Dennis Löffler, Conny Blumert, Maximilian Merz, Ulrike Köhl, Susann Dehmel, Katherina Sewald, Kristin Reiche
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Background The coordinated transcriptional regulation of activated T-cells is based on a complex dynamic behavior of signaling networks. Given an external stimulus, T-cell gene expression is characterized by impulse and sustained patterns ov
Externí odkaz:
https://doaj.org/article/ffa3005e33b34cc29a0db10630ff1cf6
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Testis is the only organ supporting sperm production and with the largest number of proteins and tissue-specific proteins in animals. In our previous studies, we have found that knockdown of ocnus (ocn), a testis-specific gene, re
Externí odkaz:
https://doaj.org/article/d51d956c17144d519817f135739d65dd
Publikováno v:
Genes, Vol 15, Iss 4, p 521 (2024)
The nomenclature of star alleles has been widely used in pharmacogenomics to enhance treatment outcomes, predict drug response variability, and reduce adverse reactions. However, the discovery of numerous rare functional variants through genome seque
Externí odkaz:
https://doaj.org/article/2796a777db16409b8555721470aab479
Autor:
Binxue Kong, Jingfu Ma, Peipei Zhang, Tao Chen, Yuan Liu, Zhuo Che, Fahimeh Shahinnia, Delong Yang
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background Grain yield is a complex and polygenic trait influenced by the photosynthetic source-sink relationship in wheat. The top three leaves, especially the flag leaf, are considered the major sources of photo-assimilates accumulated in
Externí odkaz:
https://doaj.org/article/5211dff5269c476e8efe536fb3b0ad8d
Publikováno v:
Fishes, Vol 8, Iss 10, p 521 (2023)
During winter, stream fishes are vulnerable to semi-aquatic predators like mammals and birds and reduce encounters by being active in darkness or under surface ice. Less is known about the behavior of fishes towards instream piscivorous fishes. Here,
Externí odkaz:
https://doaj.org/article/0bab28ebb5df454c997ed6b7495c56a7
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Accurate evaluation of human epidermal growth factor receptor 2 (HER2) status is of great importance for appropriate management of advanced gastric cancer (AGC) patients. This study aims to develop and validate a CT-based radiomics model
Externí odkaz:
https://doaj.org/article/ce3ac0f4f7f642fa8de4da08884791e1
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Previous studies revealed that the gene signatures are associated with the modulation and pathogenesis of pulmonary arterial hypertension (PAH). However, identifying critical transcriptional signatures in the blood of PAH patients remains
Externí odkaz:
https://doaj.org/article/e7f31cbf5480420c8004e7c56aa4f4cc