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Autor:
Carlijn A. Hoekx, Maaike E. Straat, Maurice B. Bizino, Huub J. vanEyk, Hildebrandus J. Lamb, Johannes W. A. Smit, Ingrid M. Jazet, Saskia C. A. deJager, Mariëtte R. Boon, Borja Martinez‐Tellez
Publikováno v:
Experimental Physiology, Vol 109, Iss 8, Pp 1292-1304 (2024)
Abstract Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists induce weight loss in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is unclear. Recently, the mechanism by which metformin induces weight loss could be ex
Externí odkaz:
https://doaj.org/article/480115ade2eb4c9e882a6403f123df23
Autor:
Jason Tallis, Rob S. James, Emma L. J. Eyre, Sharn P. Shelley, Cameron Hill, Derek Renshaw, Josh Hurst
Publikováno v:
Experimental Physiology, Vol 109, Iss 7, Pp 1163-1176 (2024)
Abstract Despite evidence inferring muscle and contractile mode‐specific effects of high‐fat diet (HFD), no study has yet considered the impact of HFD directly on eccentric muscle function. The present work uniquely examined the effect of 20‐we
Externí odkaz:
https://doaj.org/article/28fa9a83f9c0434287d2d821f85e6d8c
Autor:
Michelle L. Kearns, Clare M. Reynolds
Publikováno v:
Experimental Physiology, Vol 109, Iss 5, Pp 633-646 (2024)
Abstract Pregnancy represents a period of immense maternal physiological adaptation, with progressive increases in lipid storage potential and insulin resistance to support fetal/placental growth. This requires significant change in the adipose tissu
Externí odkaz:
https://doaj.org/article/0fe0a306afad4fbc99827f43607c25e9
Publikováno v:
Ожирение и метаболизм, Vol 21, Iss 1, Pp 58-67 (2024)
The prevalence of obesity and type 2 diabetes continues to grow, which determines the need to develop new methods of prevention in order to reduce the population risks of developing these diseases. The current direction is to limit the consumption of
Externí odkaz:
https://doaj.org/article/7215cc37dc7c46babcd2e91f99a1f636
Autor:
A. V. Shestopalov, V. V. Davydov, G. T. Tumanyan, E. D. Teplyakova, T. P. Shkurat, E. V. Mashkina, M. A. Shkurat, A. M. Gaponov, O. V. Borisenko, S. A. Roumiantsev
Publikováno v:
Ожирение и метаболизм, Vol 21, Iss 1, Pp 31-41 (2024)
BACKGROUND: A special role in the development of obesity is given to the genetic polymorphism of lipid metabolism enzymes, which include triacylglycerol lipase. However, there is still no information about the relationship between the single nucleoti
Externí odkaz:
https://doaj.org/article/d7eece5cd2754068ae227c5d4a9d9c81
Autor:
S. C. Gurule, J. F. Sustaita-Monroe, L. N. King, R. S. Landers, V. Garza, S. M. West, S. E. Bynum, L. Perry, V. Padmanabhan, R. C. Cardoso
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in women of reproductive age, and obesity can increase the severity and development of the PCOS phenotype. Prenatal testosterone (T) treatment between gestational days 3
Externí odkaz:
https://doaj.org/article/af21f4362ef645e7a2276ec765621bfd
Autor:
Yuxiu Li, Zimengwei Ye, Yi Zhao, Bingrui Xu, Wanying Xue, Zhufeng Wang, Ran An, Fan Wang, Rui Wu
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
BackgroundLing-gui-zhu-gan (LGZG) formula has been demonstrated to effectively ameliorate the clinical symptoms of patients with obesity or metabolic syndrome. This study aimed to explore both the effect and the underlying mechanisms of LGZG against
Externí odkaz:
https://doaj.org/article/550e7c39cfa6464c922e224a8333d0c7
Autor:
Mahdokht Mahmoodi, Elahe Mirzarazi Dahagi, Mir‐Hamed Nabavi, Ylauna C. M. Penalva, Amrita Gosaine, Monzur Murshed, Sandrine Couldwell, Lisa M. Munter, Mari T. Kaartinen
Publikováno v:
Physiological Reports, Vol 12, Iss 14, Pp n/a-n/a (2024)
Abstract Plasma fibronectin (pFN) is a hepatocyte‐derived circulating extracellular matrix protein that affects cell morphology, adipogenesis, and insulin signaling of adipocytes in vitro. In this study, we show pFN accrual to adipose tissue and it
Externí odkaz:
https://doaj.org/article/98eab24d4b3746e0a419bb46aede5a2e
Autor:
Gary S. Goldfield, Jameason D. Cameron, Ronald J. Sigal, Glen P. Kenny, Denis Prud'homme, Mathew Ngu, Angela S. Alberga, Steve Doucette, Diana B. Goldfield, Heather Tulloch, Helen Thai, Kevin R. Simas, Jeremy Walsh
Publikováno v:
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024)
Abstract The brain derived‐neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health‐related quality of life (HRQoL) remains u
Externí odkaz:
https://doaj.org/article/600340e1eb644d5782c77952981570dd
Autor:
Kristín J. Bjarnadóttir, Gaetano Perchiazzi, Caroline Lördal Sidenbladh, Aleksandra Larina, Ewa Wallin, Ing-Marie Larsson, Stephanie Franzén, Anders O. Larsson, Mayson L. A. Sousa, Monica Segelsjö, Tomas Hansen, Robert Frithiof, Michael Hultström, Miklos Lipcsey, Mariangela Pellegrini
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
BackgroundThe effects of obesity on pulmonary gas and blood distribution in patients with acute respiratory failure remain unknown. Dual-energy computed tomography (DECT) is a X-ray-based method used to study regional distribution of gas and blood wi
Externí odkaz:
https://doaj.org/article/d6a4bb0dbf694d4d87d86ca3b39e3884