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Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Inflammation is a key pathological feature of many diseases, disrupting normal tissue structure and resulting in irreversible damage. Despite the need for effective inflammation control, current treatments, including stem cell therapies, rem
Externí odkaz:
https://doaj.org/article/960ca00575c540afa736170d774ea2e8
Autor:
Cuifang Li, Feifeng Wu, Jueyi Mao, Yang Wang, Junquan Zhu, Kimsor Hong, Haotian Xie, Xin Zhou, Jidong Tian, Chuan Wen
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Background Human umbilical cord mesenchymal stem cells-derived extracellular vesicles (hUCMSC-EVs) have potent immunomodulatory properties similar to parent cells. This study investigated the therapeutic effects and immunomodulatory mechanis
Externí odkaz:
https://doaj.org/article/fff780a687884b3db3e971e2aa85923e
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Cardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortality rates of neoplastic diseases. Extracellular vesicles (EVs) serve as vital mediators in intercellular communication an
Externí odkaz:
https://doaj.org/article/67f6599d1fa94625b47c189a81f565e6
Autor:
Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of
Externí odkaz:
https://doaj.org/article/7d2ff81e56f648e2ad983488d3bcd62f
Autor:
Abhijna Ballal R, Shivakumar Reddy K, Divya Chandran, Sumukha Hegde, Raghavendra Upadhya, Praveen Kumar SE, Smita Shenoy, Vasudha Devi, Dinesh Upadhya
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Epilepsy affects ∼60 million people worldwide. Most antiseizure medications in the market act on voltage-gated sodium or calcium channels, indirectly modulating neurotransmitter GABA or glutamate levels or multiple targets. Earl
Externí odkaz:
https://doaj.org/article/5073bd5659304df0b8b85e27f8ccaaba
Autor:
Jing Wang, Zhong-jin Chen, Ze-yi Zhang, Mei-ping Shen, Bo Zhao, Wei Zhang, Ye Zhang, Ji-gang Lei, Cheng-jie Ren, Jing Chang, Cui-li Xu, Meng Li, Yang-yang Pi, Tian-lun Lu, Cheng-xiang Dai, Su-ke Li, Ping Li
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Background Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have been shown to alleviate inflammation in acute lung injury (ALI) animal models. However, there are few systemic studies on clinical-grade haMSC-EVs. Our st
Externí odkaz:
https://doaj.org/article/35557ee36850403693b72a0f7ff77ef1
Autor:
Federica Virla, Ermanna Turano, Ilaria Scambi, Lorenzo Schiaffino, Marina Boido, Raffaella Mariotti
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Spinal Muscular Atrophy (SMA) is an autosomal-recessive neuromuscular disease affecting children. It is caused by the mutation or deletion of the survival motor neuron 1 (SMN1) gene resulting in lower motor neuron (MN) degeneratio
Externí odkaz:
https://doaj.org/article/a86a1f0bb8ae46af860d3afdbdd33e5f
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Premature ovarian insufficiency (POI) is an essential cause of reduced fertility and quality of life in young women. Mesenchymal stem cells (MSCs) and MSCs-derived extracellular vesicles (EVs) have the ability to migrate to damaged tissues a
Externí odkaz:
https://doaj.org/article/ff12e505507f44f58d84dee1a0d62bb4
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-18 (2024)
Abstract Background Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS). Our current study tried to elucidate the possible role of macrophage-EV loaded with small interfering RNA
Externí odkaz:
https://doaj.org/article/c5ccd958525943c49eb3c26cbcd5b352
Autor:
John A. Kink, Michael A. Bellio, Matthew H. Forsberg, Alexandra Lobo, Anna S. Thickens, Bryson M. Lewis, Irene M. Ong, Aisha Khan, Christian M. Capitini, Peiman Hematti
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to infections and death. We and others have shown that cellular therap
Externí odkaz:
https://doaj.org/article/7f0ca311f8c14580a85604f16c531ec9