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Autor:
Mai M. Abdelmoaty, Eugene Lu, Rana Kadry, Emma G. Foster, Shaurav Bhattarai, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-23 (2023)
Abstract Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy neurites, and cytoplasmic inclusions in both neurons and gli
Externí odkaz:
https://doaj.org/article/2c505cc77c0f419ab35ba80333b7b3fd
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Background Parkinson’s disease (PD), a highly prevalent neuro-motor disorder is caused due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of brain. This leads to depleted dopamine (DA) content at striatum,
Externí odkaz:
https://doaj.org/article/4ac7a6e4d1474e80aa375dc6217461c5
Autor:
Xing-Yang Liu, Ke Wang, Xian-Hua Deng, Yi-Hua Wei, Rui Guo, Sui-Feng Liu, Yi-Fan Zhu, Jia-Jun Zhong, Jing-Yuan Zheng, Meng-Dan Wang, Qiu-Hong Ye, Jian-Quan He, Kai-Hang Guo, Jun-Rong Zhu, Shu-Qiong Huang, Ze-Xu Chen, Chong-Shan Lv, Lei Wen
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Background Olfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease (PD). As the foremost pathological hallmark, α-synuclein initiates the pathology in the olfactory pathway at the early stage of PD, particula
Externí odkaz:
https://doaj.org/article/c34f41dbf0de4dbf91248e78e67e5a0c
Autor:
Alexander Blagov, Anton Postnov, Vasily Sukhorukov, Mikhail Popov, Jamol Uzokov, Alexander Orekhov
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 36 (2024)
Parkinson’s disease (PD) is characterized by the degeneration of the dopaminergic neurons of the corpus striatum, which can be caused by the disruption of processes of mitochondrial homeostasis, including mitophagy, mitochondrial fusion and divisio
Externí odkaz:
https://doaj.org/article/b440d311b69043d6aca5404e8e115997
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 4 (2024)
Background: The current standard for Parkinson’s disease (PD) diagnosis is often imprecise and expensive. However, the dysregulation patterns of microRNA (miRNA) hold potential as a reliable and effective non-invasive diagnosis of PD. Methods: We u
Externí odkaz:
https://doaj.org/article/58d8d8345a5f4baa87d820c61ebf83e0
Autor:
Jozef Nahalka
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 11, p 292 (2023)
Background: As a chronic degenerative disorder of the central nervous system that affects both motor and non-motor systems, Parkinson’s disease (PD) is very complex, and explanations and models are needed to better understand how dopaminergic neuro
Externí odkaz:
https://doaj.org/article/64a10c79d6d54be6a76edf2b8d562ffc
Autor:
Nicola D’Ascenzo, Emanuele Antonecchia, Antonella Angiolillo, Victor Bender, Marco Camerlenghi, Qingguo Xie, Alfonso Di Costanzo
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Background Parkinson’s Disease (PD) is the second most frequent degenerative disorder, the risk of which increases with age. A preclinical PD diagnostic test does not exist. We identify PD blood metabolites and metabolic pathways significa
Externí odkaz:
https://doaj.org/article/12d5e84ebf184fc8ab5da6c707f1a6b0
Publikováno v:
The Ukrainian Biochemical Journal, Vol 94, Iss 1, Pp 33-43 (2022)
Hematological and immunological markers of systemic inflammation were studied in 6-hydroxydopamine (6-OHDA)- and lipopolysaccharide (LPS)-induced models of Parkinson’s disease (PD). Experiments were carried out on adult male Wistar rats: 1 – inta
Externí odkaz:
https://doaj.org/article/6383562543564c059e975c426b183192
Autor:
Richard H. W. Funk, Manfred Fähnle
Publikováno v:
Frontiers in Bioscience-Scholar, Vol 13, Iss 2, Pp 181-189 (2021)
This study reviews the use of magnetic and electromagnetic fields (EMF), pulsed electromagnetic fields (PEMF), and transcranial magnetic stimulation (TMS) in Parkinson’s disease, Alzheimer’s disease (AD), or Multiple Sclerosis (MS). The Introduct
Externí odkaz:
https://doaj.org/article/81cf3973ed714f1c9fbeb63d1c515bac
Autor:
Shaswati Sarma, Shiny Derose, Nagamaniammai Govindarajan, Musthafa Mohamed Essa, M. Walid Qoronfleh, Saravana Babu Chidambaram, Buthaina Al-Bulushi
Publikováno v:
Frontiers in Bioscience-Scholar, Vol 13, Iss 2, Pp 131-140 (2021)
Coenzyme Q10 (CoQ10) is an antioxidant, fat-soluble component present in the mitochondrial cells. It provides beneficial results in the treatment of male infertility. In the current scenario, the sedative lifestyle, diet and stress in human lead to e
Externí odkaz:
https://doaj.org/article/c95acad6fbee4d32bf9122fe7e51fcb2