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Autor:
Shaswati Sarma, Shiny Derose, Nagamaniammai Govindarajan, Musthafa Mohamed Essa, M. Walid Qoronfleh, Saravana Babu Chidambaram, Buthaina Al-Bulushi
Publikováno v:
Frontiers in Bioscience-Scholar, Vol 13, Iss 2, Pp 131-140 (2021)
Coenzyme Q10 (CoQ10) is an antioxidant, fat-soluble component present in the mitochondrial cells. It provides beneficial results in the treatment of male infertility. In the current scenario, the sedative lifestyle, diet and stress in human lead to e
Externí odkaz:
https://doaj.org/article/c95acad6fbee4d32bf9122fe7e51fcb2
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1503-1512 (2021)
Introduction: Parkinson’s disease (PD) is caused by the interplay of genetic and environmental factors during brain aging. About 90 single nucleotide polymorphisms (SNPs) have been recently discovered associations with PD, but whether they associat
Externí odkaz:
https://doaj.org/article/37051d308e294f6c80e797b32fa19823
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the deficits in periphery organs or tissues occur in PD patients, and what are the relationsh
Externí odkaz:
https://doaj.org/article/fb9cc548fd604b8d828b13e62d3f18f9
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-24 (2021)
Abstract Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-synuclein protein inexorably u
Externí odkaz:
https://doaj.org/article/132f2e779abe473f8e4a5e4bfd3b76e0
Autor:
Simon Haron, Ethan J Kilmister, Paul F Davis, Stanley S Stylli, Theo Mantamadiotis, Andrew H Kaye, Sean R Hall, Swee T Tan, Agadha C Wickremesekera
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 9, Pp 628-642 (2021)
Despite their differences, central nervous system (CNS) tumors and degenerative diseases share important molecular mechanisms underlying their pathologies, due to their common anatomy. Here we review the role of the renin-angiotensin system (RAS) in
Externí odkaz:
https://doaj.org/article/04816149c3aa4ff098288b3e5db93243
Autor:
Kenneth Maiese
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 9, Pp 614-627 (2021)
Introduction: Dementia and cognitive loss impact a significant proportion of the global population and present almost insurmountable challenges for treatment since they stem from multifactorial etiologies. Innovative avenues for treatment are highly
Externí odkaz:
https://doaj.org/article/72736c9e6fdc447591cfb19f1c5d7a89
Autor:
Bipul Ray, Girish Ramesh, Sudhir Rama Verma, Srinivasan Ramamurthy, Sunanda Tuladhar, Arehally Marappa Mahalakshmi, Musthafa Mohamed Essa, Saravana Babu Chidambaram
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 8, Pp 262-271 (2021)
Background: Mitochondrial dysfunction plays a crucial role in Parkinson’s disease (PD) pathogenesis. The present study was undertaken to investigate the effects of Telmisartan (TEL), an angiotensin II type 1 receptor (AT1R) blocker, on the mitochon
Externí odkaz:
https://doaj.org/article/5fc7050063094003bb74fbc39f4bda85
Autor:
James D. Adams
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 8, Pp 387-394 (2021)
Parkinson’s disease, in most patients, is possibly caused by natural oxidative stress in dopaminergic neurons, insufficient exercise and galactose induced oxidative stress. Dopamine oxidizes to produce oxygen radicals that damage neurons. Exercise
Externí odkaz:
https://doaj.org/article/55b58557cff4410c82a9377585eb9a61
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Background ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, and its defection plays an important role in mitochondrial pathogenesis. To reveal an etiological implication of ANT1 for Parkinson
Externí odkaz:
https://doaj.org/article/22653c7415c24344b438be4ded5edc64
Autor:
Marc Dahlmanns, Jana Katharina Dahlmanns, Nicolai Savaskan, Hans-Herbert Steiner, Eduard Yakubov
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 3, p 57 (2023)
Glial cells play an essential role in the complex function of the nervous system. In particular, astrocytes provide nutritive support for neuronal cells and are involved in regulating synaptic transmission. Oligodendrocytes ensheath axons and support
Externí odkaz:
https://doaj.org/article/49b1882f87e64b82bbbec1796c2670cb