Zobrazeno 1 - 10
of 17
pro vyhledávání: ''
Autor:
Qinhao Wang, Yuanyuan Su, Ruiqi Sun, Xin Xiong, Kai Guo, Mengying Wei, Guodong Yang, Yi Ru, Zhengxiang Zhang, Jing Li, Jing Zhang, Qing Qiao, Xia Li
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Background The enrichment of peri-cancerous adipose tissue is a distinctive feature of colorectal cancer (CRC), accelerating disease progression and worsening prognosis. The communication between tumor cells and adjacent adipocytes plays a c
Externí odkaz:
https://doaj.org/article/c6c9723a741d47ae815822ef335e3410
Autor:
Martina Lepore Signorile, Candida Fasano, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Cristiano Simone, Valentina Grossi
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Background Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β through phosphoryl
Externí odkaz:
https://doaj.org/article/b1012b50cb79450496cd287a38de5e67
Autor:
Zhenyu Xie, Liaoran Niu, Gaozan Zheng, Kunli Du, Songchen Dai, Ruikai Li, Hanjun Dan, Lili Duan, Hongze Wu, Guangming Ren, Xinyu Dou, Fan Feng, Jian Zhang, Jianyong Zheng
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This study used a multi-omics approach, integrating single-cell sequencing, spatial transcripto
Externí odkaz:
https://doaj.org/article/8be01300fcfc46e8a8891e2889598206
Autor:
Ting Wang, Longci Sun, Chengkun Chen, Yingchao Zhang, Baoyu He, Yanhua Zhang, Zhenghe Wang, Hanbing Xue, Yujun Hao
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background PI3K/AKT signaling pathway plays important role in tumorigenesis of human cancer. Protein phosphorylation is crucial for signaling transduction of this pathway. PIK3CA, encoding the catalytic subunit p110α of PI3K complex, is one
Externí odkaz:
https://doaj.org/article/7e2775013f4a4ef3bd9add2c49288dfc
Autor:
Mujie Ye, Jinhao Chen, Feiyu Lu, Minghui Zhao, Suwen Wu, Chunhua Hu, Ping Yu, Jingbao Kan, Jianan Bai, Ye Tian, Qiyun Tang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Background N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal cancer (CRC). This s
Externí odkaz:
https://doaj.org/article/0fdd6ee2cce940408541e7049bc4db79
Autor:
Sara Cherradi, Véronique Garambois, Johanna Marines, Augusto Faria Andrade, Alexandra Fauvre, Olivia Morand, Manon Fargal, Ferial Mancouri, Adeline Ayrolles-Torro, Nadia Vezzo-Vié, Marta Jarlier, Gerald Loussaint, Steve Huvelle, Nicolas Joubert, Thibault Mazard, Céline Gongora, Philippe Pourquier, Florence Boissière-Michot, Maguy Del Rio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Background Tumor resistance is a frequent cause of therapy failure and remains a major challenge for the long-term management of colorectal cancer (CRC). The aim of this study was to determine the implication of the tight junctional protein
Externí odkaz:
https://doaj.org/article/612613fc1c27490d8675f675e72b711a
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract With high prevalence and mortality, together with metabolic reprogramming, colorectal cancer is a leading cause of cancer-related death. Metabolic reprogramming gives tumors the capacity for long-term cell proliferation, making it a distingu
Externí odkaz:
https://doaj.org/article/2e8af8c80ee34812a8afed0827d79974
Autor:
Junfeng Xu, Zhijun Zheng, Lang Yang, Ruoran Li, Xianzong Ma, Jie Zhang, Fumei Yin, Lin Liu, Qian Xu, Qiujing Shen, Xiuping Shen, Chunyan Wu, Jing Liu, Nan Qin, Jianqiu Sheng, Peng Jin
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Background Colorectal cancer (CRC), a commonly diagnosed cancer often develops slowly from benign polyps called adenoma to carcinoma. Altered gut microbiota is implicated in colorectal carcinogenesis. It is warranted to find non-invasive pro
Externí odkaz:
https://doaj.org/article/f7b4598228b1492d8101ab76016f282c
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-17 (2022)
Highlights 1. High-throughput screening of ATG4B inhibitors based on FDA-approved drug library 2. Ebselen can covalently bind to ATG4B at Cys74 3. Ebselen can promote ATG4B oligomerization at Cys292 and Cys361 4. Ebselen suppresses the growth of colo
Externí odkaz:
https://doaj.org/article/16127599ceb44408b217c93e790335c2
Autor:
Mahan Si, Yujia Song, Xiaohui Wang, Dong Wang, Xiaohui Liu, Xianjun Qu, Zhiyu Song, Xinfeng Yu
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-21 (2022)
Abstract Background Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7 biased signal has been reported to play crucial roles in multiple stages of colorectal cancer (
Externí odkaz:
https://doaj.org/article/e63ee5c269be404e822c6a4b0e98927b