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Autor:
Michele Costanzo, Armando Cevenini, Laxmikanth Kollipara, Marianna Caterino, Sabrina Bianco, Francesca Pirozzi, Gianluca Scerra, Massimo D’Agostino, Luigi Michele Pavone, Albert Sickmann, Margherita Ruoppolo
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Background Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme. As matter of fact, MMA patients manifest impairment of the primary metab
Externí odkaz:
https://doaj.org/article/d2e9f9c0ba4e4ad49dfbe4ca6132a2b4
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Background Psoriasis is an inflammatory skin disease characterized by the hyperproliferative epidermal keratinocytes and significant immune cells infiltration, leading to cytokines production such as IL-1β, TNF-α, IL-23, and IL-17. Recent
Externí odkaz:
https://doaj.org/article/0ede2e5c808b4ab489971aae89420656
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer. In cancer, dysregulated auto
Externí odkaz:
https://doaj.org/article/dbd4ff7ddede4c5f856e156e14789e11
Autor:
Damilare Emmanuel Rotimi, Matthew Iyobhebhe, Elizabeth Temidayo Oluwayemi, Ikponmwosa Owen Evbuomwan, Rotdelmwa Maimako Asaleye, Oluwafemi Adeleke Ojo, Oluyomi Stephen Adeyemi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101698- (2024)
The mitophagy process, a type of macroautophagy, is the targeted removal of mitochondria. It is a type of autophagy exclusive to mitochondria, as the process removes defective mitochondria one by one. Mitophagy serves as an additional level of qualit
Externí odkaz:
https://doaj.org/article/1babe7747b314a1aadbdc94112981bdd
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101672- (2024)
Autophagy has emerged as a critical innate immune mechanism for host elimination of intracellular pathogens, however, the role of the autophagy receptor Optineurin during mycobacterial infection is not fully understood. To address this lacuna, we inf
Externí odkaz:
https://doaj.org/article/06c3ba4c4e5a419ab08b3463e66f0c20
Autor:
Pingping Sun, Zhan Wang, Sixiao Li, Jiajing Yin, Yuyang Gan, Shizhao Liu, Zhen Lin, Hailin Wang, Zhexiang Fan, Qian Qu, Zhiqi Hu, Kaitao Li, Yong Miao
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Background Hair follicle stem cells (HFSCs) typically remain quiescent and are activated only during the transition from telogen to anagen to ensure that the hair follicle enters a new cycle. The metabolic behavior of stem cells in tissues i
Externí odkaz:
https://doaj.org/article/c785aef046d041329059d4b2174de7f8
Autor:
Kim Fredericks, Jurgen Kriel, Lize Engelbrecht, Petra Andreea Mercea, Georg Widhalm, Brad Harrington, Ian Vlok, Ben Loos
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101642- (2024)
Glioblastoma Multiforme (GBM) is the most invasive and prevalent Central Nervous System (CNS) malignancy. It is characterised by diffuse infiltrative growth and metabolic dysregulation that impairs the extent of surgical resection (EoR), contributing
Externí odkaz:
https://doaj.org/article/21e966d44823412d826240476fa5451b
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 231 (2024)
The inhibitors of mammalian target of rapapmycin (mTOR), everolimus, temsirolimus and rapamycin, have a wide range of clinical utility; however, as is inevitably the case with other chemotherapeutic agents, resistance development constrains their eff
Externí odkaz:
https://doaj.org/article/26f363ffd1e944e3bf406f4ef7ab99de
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 212 (2024)
Background: Gastric cancer (GC) is a leading cause of cancer-associated death worldwide. Its molecular mechanisms, especially concerning autophagy and various signaling pathways, are not fully understood. Fatty Acid Binding Protein 6 (FABP6) and RE1
Externí odkaz:
https://doaj.org/article/b47a57d7ada942b18291968fedc9c9c5
Autor:
Jing Nie, Hongbin Qiu
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 222 (2024)
Background: Persistent hyperuricemia can lead to the generation and deposition of monosodium urate (MSU) crystals. This can trigger gouty arthritis (GA), which in turn induces inflammation. Activation of the Nod-like receptor pyrin domain containing
Externí odkaz:
https://doaj.org/article/9621055ba88e4ab497cdbd5777e350a8