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Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
The enzymatic breakdown and regulation of food passage through the vertebrate antral stomach and pyloric sphincter (antropyloric region) is a trait conserved over 450 million years. Development of the structures involved is underpinned by a highly co
Externí odkaz:
https://doaj.org/article/82c59c9b3c6841ceae916e8dc38bf9d0
Autor:
Renata C. Barbosa, Raquel S. M. Godoy, Priscila G. Ferreira, Tiago A. O. Mendes, Marcelo Ramalho-Ortigão, José M. C. Ribeiro, Gustavo F. Martins
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
Toxorhynchites mosquitoes have an exclusively phytophagous feeding habit as adults, which leads to significant differences in their morphophysiology compared with haematophagous mosquitoes. However, the molecular mechanisms of digestion in this mosqu
Externí odkaz:
https://doaj.org/article/ceb7e654e8e6429499c1cb112d789904
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
The vertebrate organizer plays a crucial role in building the main (antero-posterior) axis of the embryo: it neuralizes the surrounding ectoderm, and is the site of emigration for cells making axial and paraxial mesendoderm during elongation. The chi
Externí odkaz:
https://doaj.org/article/1421adc1ae1a4c60afb004f5dd2934e9
Autor:
Simon Oberegger, Matthias Misslinger, Klaus Faserl, Bettina Sarg, Hesso Farhan, Hubertus Haas
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Aspergillus fumigatus is the predominant mould pathogen for humans. Adaption to host-imposed iron limitation has previously been demonstrated to be essential for its virulence. [2Fe–2S] clusters are crucial as cofactors of several metabolic pathway
Externí odkaz:
https://doaj.org/article/0576385144cc4bb8bc2cd8b0e5bde4e5
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
The transition from oocyte to embryo requires translation of maternally provided transcripts that in Drosophila is activated by Pan Gu kinase to release a rapid succession of 13 mitotic cycles. Mitotic entry is promoted by several protein kinases tha
Externí odkaz:
https://doaj.org/article/63e54156bdaa438ea4c41f50ba5bf82f
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Acid-sensing ion channels (ASICs) are neuronal Na+-permeable ion channels activated by extracellular acidification. ASICs are involved in learning, fear sensing, pain sensation and neurodegeneration. Increasing the extracellular Ca2+ concentration de
Externí odkaz:
https://doaj.org/article/a41cb0c001ba42d9a484adb76cade253
Autor:
Manu Yadav, Ishita Vaishkiar, Ananya Sharma, Akanksha Shukla, Aradhana Mohan, Madhuri Girdhar, Anil Kumar, Tabarak Malik, Anand Mohan
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Traditional medication and alternative therapies have long been used to treat breast cancer. One of the main problems with current treatments is that there is an increase in drug resistance in the cancer cells owing to genetic differences such as mut
Externí odkaz:
https://doaj.org/article/830e7e98583342e2a7267b376765e08f
Autor:
Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative compound fr
Externí odkaz:
https://doaj.org/article/ab895c6ab92c405ab16479c74bcf64ea
Autor:
Tania Aerts, Anneleen Boonen, Lieve Geenen, Anne Stulens, Luca Masin, Anna Pancho, Annick Francis, Elise Pepermans, Geert Baggerman, Frans Van Roy, Markus Wöhr, Eve Seuntjens
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions associated with deficits in social interaction and communication, together with repetitive behaviours. The cell adhesion molecule protocadherin10 (PCDH10) is linked to ASD in
Externí odkaz:
https://doaj.org/article/ac7dafdace954edc990831b666085c59
Autor:
Marc Ramos-Llorens, Khalida Bainour, Leonie Adelmann, Francisco Hontoria, Juan C. Navarro, Florian Raible, Óscar Monroig
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Elongation of very long-chain fatty acid (Elovl) proteins plays pivotal functions in the biosynthesis of the physiologically essential long-chain polyunsaturated fatty acids (LC-PUFA). Polychaetes have important roles in marine ecosystems, contributi
Externí odkaz:
https://doaj.org/article/f43c1b14448a466a8355d37b190c1bc7