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of 12
pro vyhledávání: ''
Autor:
Tania Martins-Marques, Katja Witschas, Ilda Ribeiro, Mónica Zuzarte, Steve Catarino, Teresa Ribeiro-Rodrigues, Francisco Caramelo, Trond Aasen, Isabel Marques Carreira, Lino Goncalves, Luc Leybaert, Henrique Girao
Publikováno v:
Open Biology, Vol 13, Iss 11 (2023)
Classically associated with gap junction-mediated intercellular communication, connexin43 (Cx43) is increasingly recognized to possess non-canonical biological functions, including gene expression regulation. However, the mechanisms governing the loc
Externí odkaz:
https://doaj.org/article/9818ae85d1f1418e970836550652bf2d
Autor:
Elisabet Alacid, Nicholas A. T. Irwin, Vanessa Smilansky, David S. Milner, Estelle S. Kilias, Guy Leonard, Thomas A. Richards
Publikováno v:
Open Biology, Vol 12, Iss 8 (2022)
Spliced-leader trans-splicing (SLTS) has been described in distantly related eukaryotes and acts to mark mRNAs with a short 5′ exon, giving different mRNAs identical 5′ sequence-signatures. The function of these systems is obscure. Perkinsozoa en
Externí odkaz:
https://doaj.org/article/4dcffd68c3cd460785fe79a0b3b14a11
Autor:
Maritere Uriostegui-Arcos, Rodrigo Aguayo-Ortiz, María del Pilar Valencia-Morales, Erika Melchy-Pérez, Yvonne Rosenstein, Laura Dominguez, Mario Zurita
Publikováno v:
Open Biology, Vol 10, Iss 6 (2020)
Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between
Externí odkaz:
https://doaj.org/article/ee28c7419a534ba9b9149e592f226f14
Publikováno v:
Open Biology, Vol 9, Iss 12 (2019)
An important capacity of genes is the rapid change of expression levels to cope with the environment, known as expression responsiveness or plasticity. Elucidating the genomic mechanisms determining expression plasticity is critical for understanding
Externí odkaz:
https://doaj.org/article/3e246e053795463481feb3c5f5c8784a
Publikováno v:
Open Biology, Vol 9, Iss 10 (2019)
The vast majority of cell biological studies examine function and molecular mechanisms using cells on flat surfaces: glass, plastic and more recently elastomeric polymers. While these studies have provided a wealth of valuable insight, they fail to c
Externí odkaz:
https://doaj.org/article/1373e991c04645178e79214b1eb5269a
Autor:
Stefan Bresson, David Tollervey
Publikováno v:
Open Biology, Vol 8, Iss 3 (2018)
Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which are subject to extensive processing. These processes are inherently error-prone, and cells have evolved robust quality control mechanisms to selectively remove
Externí odkaz:
https://doaj.org/article/be8ac45f435b4227b5c45276fc95f875
Autor:
Nicholas J. Bradshaw, Liisa Ukkola-Vuoti, Maiju Pankakoski, Amanda B. Zheutlin, Alfredo Ortega-Alonso, Minna Torniainen-Holm, Vishal Sinha, Sebastian Therman, Tiina Paunio, Jaana Suvisaari, Jouko Lönnqvist, Tyrone D. Cannon, Jari Haukka, William Hennah
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Genetic studies of familial schizophrenia in Finland have observed significant associations with a group of biologically related genes, DISC1, NDE1, NDEL1, PDE4B and PDE4D, the ‘DISC1 network’. Here, we use gene expression and psychoactive medica
Externí odkaz:
https://doaj.org/article/4b629c90c56d4cd896a19d72e6ebdeb4
Publikováno v:
Open Biology, Vol 7, Iss 1 (2017)
Studies dating back to the 1970s established that sequence complementarity between the anti-Shine–Dalgarno (aSD) sequence on prokaryotic ribosomes and the 5′ untranslated region of mRNAs helps to facilitate translation initiation. The optimal loc
Externí odkaz:
https://doaj.org/article/e7da224c82b743be8bed0eb179194568
Autor:
Luis Miguel De Pablos, Steve Kelly, Janaina de Freitas Nascimento, Jack Sunter, Mark Carrington
Publikováno v:
Open Biology, Vol 7, Iss 4 (2017)
The fate of an mRNA is determined by its interaction with proteins and small RNAs within dynamic complexes called ribonucleoprotein complexes (mRNPs). In Trypanosoma brucei and related kinetoplastids, responses to internal and external signals are ma
Externí odkaz:
https://doaj.org/article/038a65615a434f23805c7029f765c113
Publikováno v:
Open Biology, Vol 6, Iss 2 (2016)
Human cells express four mitochondrial adenine nucleotide translocase (hANT) isoforms that are tissue-specific and developmentally regulated. hANT1 is mainly expressed in terminally differentiated muscle cells; hANT2 is growth-regulated and is upregu
Externí odkaz:
https://doaj.org/article/cca5e53ef38d4ab4bf9ed49ba7c48d10