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pro vyhledávání: ''
Autor:
Virender K. Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers, Joern R. Steinert, Linda Partridge, Hrvoje Augustin
Publikováno v:
Open Biology, Vol 13, Iss 9 (2023)
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β sup
Externí odkaz:
https://doaj.org/article/52604fc9b84246b693fbae8899b28894
Publikováno v:
Open Biology, Vol 12, Iss 12 (2022)
Dietary interventions that restrict protein intake have repeatedly been shown to offer beneficial health outcomes to the consumer. Benefits such as increased stress tolerance can be observed when individual amino acids are restricted, thus mimicking
Externí odkaz:
https://doaj.org/article/60b6fe7ced104266a82df136e6570ad5
Autor:
Haiko Poppinga, Büşra Çoban, Hagar Meltzer, Oded Mayseless, Annekathrin Widmann, Oren Schuldiner, André Fiala
Publikováno v:
Open Biology, Vol 12, Iss 9 (2022)
The principles of how brain circuits establish themselves during development are largely conserved across animal species. Connections made during embryonic development that are appropriate for an early life stage are frequently remodelled later in on
Externí odkaz:
https://doaj.org/article/339f8ba972124182a919e3808ed0d594
Autor:
Dick R. Nässel, Meet Zandawala
Publikováno v:
Open Biology, Vol 12, Iss 7 (2022)
Plasticity in animal behaviour relies on the ability to integrate external and internal cues from the changing environment and hence modulate activity in synaptic circuits of the brain. This context-dependent neuromodulation is largely based on non-s
Externí odkaz:
https://doaj.org/article/d69885f483f54c2da305ebf669066927
Autor:
Alexandra D. Rusu, Zoe E. Cornhill, Brenda Canales Coutiño, Marcos Castellanos Uribe, Anbarasu Lourdusamy, Zsuzsa Markus, Sean T. May, Ruman Rahman, Marios Georgiou
Publikováno v:
Open Biology, Vol 11, Iss 9 (2021)
Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established role
Externí odkaz:
https://doaj.org/article/ac1db539b5b844c9955fe2fded805808
Autor:
Katherine H. Shaw, Craig I. Dent, Travis K. Johnson, Alisha Anderson, Marien de Bruyne, Coral G. Warr
Publikováno v:
Open Biology, Vol 11, Iss 9 (2021)
In insects, many critical olfactory behaviours are mediated by the large odorant receptor (Or) gene family, which determines the response properties of different classes of olfactory receptor neurons (ORNs). While ORN responses are generally conserve
Externí odkaz:
https://doaj.org/article/ea35fff37cf34e2199bb3a38f4026a82
Publikováno v:
Open Biology, Vol 11, Iss 2 (2021)
In both mammals and insects, steroid hormones play a major role in directing the animal's progression through developmental stages. To maximize fitness outcomes, steroid hormone production is regulated by the environmental conditions experienced by t
Externí odkaz:
https://doaj.org/article/47d02876fc634fb2b47e2b808fdb9b63
Autor:
Roberto Contestabile, Martino Luigi di Salvo, Victoria Bunik, Angela Tramonti, Fiammetta Vernì
Publikováno v:
Open Biology, Vol 10, Iss 3 (2020)
A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different human diseases, including cancer and neurological disorders. Several data converge towards a crucial role played by many micronutrients in genome integrity main
Externí odkaz:
https://doaj.org/article/3902a06c081a49d09f6b0f72605c3de8
Publikováno v:
Open Biology, Vol 9, Iss 11 (2019)
In this review, we will summarize model organisms used by scientists in the laboratory, including Escherichia coli, yeast, Arabidopsis thaliana, nematodes, Drosophila, zebrafish, mice and other animals. We focus on the progress in research exploring
Externí odkaz:
https://doaj.org/article/b478eee28f4449bf905097fd6eeeb5b5
Publikováno v:
Open Biology, Vol 9, Iss 2 (2019)
Precise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in devel
Externí odkaz:
https://doaj.org/article/ab1c8dad6ab0453d8211c92d58c925c3