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Autor:
Selena G. Burgess, Arkadiusz Oleksy, Tommaso Cavazza, Mark W. Richards, Isabelle Vernos, David Matthews, Richard Bayliss
Publikováno v:
Open Biology, Vol 6, Iss 7 (2016)
The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric inhibitors are generally
Externí odkaz:
https://doaj.org/article/2820594c87364055b2ad1264321e04fc
Autor:
Helen I. Woodroof, Joe H. Pogson, Mike Begley, Lewis C. Cantley, Maria Deak, David G. Campbell, Daan M. F. van Aalten, Alexander J. Whitworth, Dario R. Alessi, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 1, Iss 3 (2011)
Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-recessive Parkinson's disease. To date, little is known about the intrinsic catalytic properties of PINK1 since the human enzyme displays su
Externí odkaz:
https://doaj.org/article/2c6dad7c43e549d7be7f383bd93c8f93