Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Preclinical research"'
Autor:
Angel Moctezuma-Ramirez, David Dworaczyk, Julia Whitehorn, Ke Li, Cristiano de Oliveira Cardoso, Abdelmotagaly Elgalad
Publikováno v:
Surgeries, Vol 4, Iss 4, Pp 544-555 (2023)
During the preclinical research process, multiple factors can be difficult to implement without the careful consideration and planning of each step. As research has become more advanced with the use of increasingly complex technology, animal models h
Externí odkaz:
https://doaj.org/article/47198ec6e09c4494a3bd88ba6cc79d7e
Autor:
Renata Torres Pessoa, Isabel Sousa Alcântara, Lucas Yure Santos da Silva, Roger Henrique Souza da Costa, Tarcísio Mendes Silva, Cícera Datiane de Morais Oliveira-Tintino, Andreza Guedes Barbosa Ramos, Maria Rayane Correia de Oliveira, Anita Oliveira Brito Pereira Bezerra Martins, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Edlane Martins de Andrade, Jaime Ribeiro-Filho, Clara Mariana Gonçalves Lima, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Publikováno v:
Analytica, Vol 4, Iss 2, Pp 141-158 (2023)
Ximenia americana L., popularly known in Brazil as “ameixa do-mato, ameixa-brava, and ameixa-do-sertão,” is widely used in folk medicine to treat several intestinal disorders. The present study assessed the potential mechanisms of action underly
Externí odkaz:
https://doaj.org/article/62e7ba74f66e4086a0ba73e55cb119ba
Publikováno v:
Animals, Vol 14, Iss 4, p 651 (2024)
Background: Research model selection decisions in basic and preclinical biomedical research have not yet been the subject of an ethical investigation. Therefore, this paper aims, (1) to identify a spectrum of reasons for choosing between animal and a
Externí odkaz:
https://doaj.org/article/9b4b4925283442ea8bfc410b06b8308f
Autor:
Suyog Khochare, R. R. Senji Laxme, Priyanka Jaikumar, Navneet Kaur, Saurabh Attarde, Gerard Martin, Kartik Sunagar
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9516 (2023)
The socioeconomic impact of snakebites in India is largely attributed to a subset of snake species commonly known as the ‘big four’. However, envenoming by a range of other clinically important yet neglected snakes, a.k.a. the ‘neglected many
Externí odkaz:
https://doaj.org/article/8b43fa6a56c24c34adaeca803b58e0be
Autor:
Laurie M. C. Kerkhof, Bart P. C. van de Warrenburg, Willeke M. C. van Roon-Mom, Ronald A. M. Buijsen
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 788 (2023)
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder that affects one or two individuals per 100,000. The disease is caused by an extended CAG repeat in exon 8 of the ATXN1 gene and is characterized mostly by a pro
Externí odkaz:
https://doaj.org/article/4888d42cc32e418c8e6a903017e98a9b
Autor:
Joana Martins-Macedo, António Mateus-Pinheiro, Cátia Alves, Fernando Veloso, Eduardo D. Gomes, Inês Ribeiro, Joana S. Correia, Tiago Silveira-Rosa, Nuno D. Alves, Ana J. Rodrigues, João M. Bessa, Nuno Sousa, João F. Oliveira, Patrícia Patrício, Luísa Pinto
Publikováno v:
Cells, Vol 12, Iss 3, p 381 (2023)
Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscien
Externí odkaz:
https://doaj.org/article/7723621b9e8a4eba90aabb4fb3adc554
Autor:
Caterina Lonati, Daniele Dondossola, Laimdota Zizmare, Michele Battistin, Leonie Wüst, Luigi Vivona, Margherita Carbonaro, Alberto Zanella, Stefano Gatti, Andrea Schlegel, Christoph Trautwein
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 538 (2022)
Machine perfusion (MP) allows the maintenance of liver cells in a metabolically active state ex vivo and can potentially revert metabolic perturbations caused by donor warm ischemia, procurement, and static cold storage (SCS). The present preclinical
Externí odkaz:
https://doaj.org/article/bbb0c8a181f24b3497976bc716ee88b2
Autor:
Mariana Matias, Jacinta O. Pinho, Maria João Penetra, Gonçalo Campos, Catarina Pinto Reis, Maria Manuela Gaspar
Publikováno v:
Cells, Vol 10, Iss 11, p 3088 (2021)
Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective,
Externí odkaz:
https://doaj.org/article/c9bd8ca4173949738bc5f7d540a5d5c3
Autor:
Jacek Zborowski, Dorota Kida, Aleksandra Szarwaryn, Karol Nartowski, Patrycja Rak, Kamil Jurczyszyn, Tomasz Konopka
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 16, p 3673 (2021)
Background: The aim of the study was to compare the effectiveness of photodynamic therapy (PDT) to steroid therapy in the treatment of oral lichen planus (OLP). Due to the lack of commercially available drug carriers, innovative proprietary solutions
Externí odkaz:
https://doaj.org/article/57631e09a2b24221bbb123019607130e
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7149 (2021)
Autologous chondrocyte implantation (ACI) is a cell therapy for the treatment of focal cartilage defects. The ACI product that is currently approved for use in the European Union (EU) consists of spheroids of autologous matrix-associated chondrocytes
Externí odkaz:
https://doaj.org/article/ad046fb2fada4d609833d81be82634ac