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Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 5, p 174 (2024)
Background: Colorectal cancer (CRC) is a major cause of mortality and morbidity. A study proved that brexpiprazole, as a novel dopamine receptor partial agonist, can also prevent CRC cell proliferation. Therefore, clarifying the molecular mechanism o
Externí odkaz:
https://doaj.org/article/0b47ff4dd00044cc8228f455c4dcdb00
Autor:
Mahdi Hosseini Bafghi, Farangis Ghanipour, Razieh Nazari, Seyed Soheil Aghaei, Parvaneh Jafari
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 5, p 171 (2024)
Background: The antibiotic resistance of microorganisms is escalating rapidly. Infections caused by opportunistic pathogens in immunocompromised individuals have prompted researchers to seek for potent and safe antibacterial agents. The purpose of th
Externí odkaz:
https://doaj.org/article/f30ee14c63d14584b24c3e4d4fcfa8d1
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 15 (2024)
Objective: The present study aims to investigate the effect of Huaier on oxaliplatin (OXA) resistance in HCT-8 colorectal cancer (CRC) cells. Methods: Oxaliplatin-resistant HCT-8/L CRC cells were used. The Cell Counting Kit-8, western blotting, quant
Externí odkaz:
https://doaj.org/article/1f14059a407a413d97f376940cc2802d
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 12, p 348 (2023)
Breast cancer has a special tumor microenvironment compared to other solid tumors, which is usually surrounded by a large number of adipocytes that can produce and secrete fatty acids and adipokines. Adipocytes have a remodeling effect on breast canc
Externí odkaz:
https://doaj.org/article/3b3c13222f9d49d48c0e13e0426a9044
Autor:
Yanjing Peng, Jinjing Tan
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 8, p 163 (2023)
The tyrosine kinase signaling pathway is an important pathway for cell signal transduction, and is involved in regulating cell proliferation, cell cycle, apoptosis and other essential biological functions. Gene mutations involved in the tyrosine kina
Externí odkaz:
https://doaj.org/article/074b2780ba004a1d9a1f9113dd3f98d8
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 3, Pp 444-467 (2020)
Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL chimeric protein. Imatinib is first FDA approved first-line BCR-ABL targeting drug fo
Externí odkaz:
https://doaj.org/article/0a9e8e008fac48f89dadfc7412cab09d
Autor:
Ana Sofia Carvalho, Henrique Baeta, Bruno Costa Silva, Maria Carolina Strano Moraes, Cristian Bodo, Hans Christian Beck, Manuel S. Rodriguez, Mayank Saraswat, Akhilesh Pandey, Rune Matthiesen
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 3, Pp 398-436 (2020)
Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs p
Externí odkaz:
https://doaj.org/article/fd69bf5388ef4187ab9df6b5e3388fec
Publikováno v:
Frontiers in Bioscience-Scholar, Vol 14, Iss 1, p 008 (2022)
The enzymes that belong to the aldehyde dehydrogenase family are expressed in a variety of cells; yet activity of their main members characterizes stem cells, both normal and malignant. Several members of this family perform critical functions in ste
Externí odkaz:
https://doaj.org/article/7fec0c2c36fc426891c7262a26040e21
Autor:
Birgit M. Prüβ
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 2, p 065 (2022)
Severe acute respiratory syndrom coronavirus-2 (SARS CoV-2) is the causative agent of coronavirus disease-19 (Covid-19) which has been designated a worldwide pandemic by the World Health Organization on March 11, 2020. Since that time, the virus has
Externí odkaz:
https://doaj.org/article/e30c8114fef541d19adfbc2e53b1823a