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Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 3, Pp 444-467 (2020)
Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL chimeric protein. Imatinib is first FDA approved first-line BCR-ABL targeting drug fo
Externí odkaz:
https://doaj.org/article/0a9e8e008fac48f89dadfc7412cab09d
Autor:
Ana Sofia Carvalho, Henrique Baeta, Bruno Costa Silva, Maria Carolina Strano Moraes, Cristian Bodo, Hans Christian Beck, Manuel S. Rodriguez, Mayank Saraswat, Akhilesh Pandey, Rune Matthiesen
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 3, Pp 398-436 (2020)
Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs p
Externí odkaz:
https://doaj.org/article/fd69bf5388ef4187ab9df6b5e3388fec