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Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 242 (2024)
Autophagy is an evolutionarily conserved process in which intracellular macromolecules are degraded in a lysosomal-dependent manner. It is central to cellular energy homeostasis and to quality control of intracellular components. A decline in autopha
Externí odkaz:
https://doaj.org/article/23d2722e6ecb45e0aa811d702fba6906
Autor:
Marvel Megaly, Anel Turgambayeva, Ryan D. Hallam, Gregory Foran, Mark Megaly, Aleksandar Necakov
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 234 (2024)
Drosophila melanogaster has been used as a model system to identify and characterize genetic contributions to development, homeostasis, and to investigate the molecular determinants of numerous human diseases. While there exist many differences at th
Externí odkaz:
https://doaj.org/article/dfa9494efdfb406499f355f0b69a045c
Autor:
Xiaofeng Zuo, Dongyu Wang, Chuntao Tao, Xuanqi Dou, Zongrong Zhao, Jinlu Zhang, Shiyi Huang, Yue Li, Xia Zhang, Youquan Bu, Yitao Wang
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 204 (2024)
Background: Lung cancer is the primary cause of cancer-related deaths, with one of the highest incidence and mortality rates of all malignant tumors. Dysregulated expression of DEPDC1B has been reported to occur in various tumor types. However, the f
Externí odkaz:
https://doaj.org/article/78c7d602e5c6436093bc7ac7069f21df
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 5, p 182 (2024)
Choline participates in three major metabolic pathways: oxidation, phosphorylation, and acetylation. Through oxidation, choline is converted to betaine and contributes to methyl metabolism and epigenetic regulation. Through phosphorylation, choline p
Externí odkaz:
https://doaj.org/article/e2e3d92415e64bcaa3cf2f0011e4ca31
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 4, p 143 (2024)
Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes. As the principal substrate and cofactor engaged in divers
Externí odkaz:
https://doaj.org/article/34bb116012334d3e8a225e44d0e9bd7c
Autor:
Neven Žarković, Agnieszka Gęgotek, Wojciech Łuczaj, Morana Jaganjac, Suzana Borović Šunjić, Kamelija Žarković, Elzbieta Skrzydlewska
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 4, p 153 (2024)
Oxidative stress often affects the structure and metabolism of lipids, which in the case of polyunsaturated free fatty acids (PUFAs) leads to a self-catalysed chain reaction of lipid peroxidation (LPO). The LPO of PUFAs leads to the formation of vari
Externí odkaz:
https://doaj.org/article/3e1d8e9059fa4cd68bc4fdffac49f8bb
Autor:
Ailin Qiu, Xiaosha Wen, Qingshuang Zou, Lei Yin, Siqi Zhu, Yao Sheng, Yan He, Quan Liu, Dixian Luo, Zifen Guo
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 3, p 92 (2024)
Phosphoglycerate kinase 1 (PGK1) serves as a pivotal enzyme in the cellular glycolysis pathway, facilitating adenosine-triphosphate (ATP) production in tumor cells and driving the Warburg effect. PGK1 generates ATP through the reversible phosphorylat
Externí odkaz:
https://doaj.org/article/885e639df8214fb78154381a2f4241b8
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 2, p 80 (2024)
The incidence and mortality from malignant tumors continue to rise each year. Consequently, early diagnosis and intervention are vital for improving patient’ prognosis and survival. The traditional pathological tissue biopsy is currently considered
Externí odkaz:
https://doaj.org/article/db9578430fa443bc8cb69264cf38c4d4
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 2, p 67 (2024)
The body of a human has a vast array of microorganisms termed the microbiome that impacts almost every function of the body. Gene-environment interactions play a major role in making us susceptible to cancer and the microbiome is such an environmenta
Externí odkaz:
https://doaj.org/article/584ceb9c43ee46d688f72f2bc2222440
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 11, p 280 (2023)
Background: Six transmembrane epithelial antigen 1 (STEAP1) is aberrantly expressed in cancers and could therefore be a potential biomarker. This study examined the connection between STEAP1 expression and clinical features/prognosis in cancer patien
Externí odkaz:
https://doaj.org/article/9bc164b1fc23445a9509569607ad23cd