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Autor:
Raffaele Sessa, Silvia Trombetti, Alessandra Lo Bianco, Giovanni Amendola, Rosa Catapano, Elena Cesaro, Fara Petruzziello, Maria D'Armiento, Giuseppe Maria Maruotti, Giuseppe Menna, Paola Izzo, Michela Grosso
Publikováno v:
Open Biology, Vol 14, Iss 2 (2024)
Transient abnormal myelopoiesis (TAM) is a Down syndrome-related pre-leukaemic condition characterized by somatic mutations in the haematopoietic transcription factor GATA-1 that result in exclusive production of its shorter isoform (GATA-1S). Given
Externí odkaz:
https://doaj.org/article/25d54d82a9fd49ac80e2cfb705873602
Autor:
Dena Leshkowitz, Merav Kedmi, Yael Fried, David Pilzer, Hadas Keren-Shaul, Elena Ainbinder, Bareket Dassa
Publikováno v:
Open Biology, Vol 12, Iss 9 (2022)
Alternative splicing produces various mRNAs, and thereby various protein products, from one gene, impacting a wide range of cellular activities. However, accurate reconstruction and quantification of full-length transcripts using short-reads is limit
Externí odkaz:
https://doaj.org/article/03117d7b2f9f4738bb0aa8ec3cfddf5d
Autor:
Mark C. Harrison, Elias Dohmen, Simon George, David Sillam-Dussès, Sarah Séité, Mireille Vasseur-Cognet
Publikováno v:
Open Biology, Vol 12, Iss 7 (2022)
The reproductive castes of eusocial insects are often characterized by extreme lifespans and reproductive output, indicating an absence of the fecundity/longevity trade-off. The role of DNA methylation in the regulation of caste- and age-specific gen
Externí odkaz:
https://doaj.org/article/1e77a286911c41cea068e265ce225062
Autor:
Hai Xin, Xingqiang He, Jun Li, Xiaomei Guan, Xukui Liu, Yuewei Wang, Liyuan Niu, Deqiang Qiu, Xuejun Wu, Haofu Wang
Publikováno v:
Open Biology, Vol 12, Iss 2 (2022)
Abdominal aortic aneurysm (AAA) is a common and serious disease with a high mortality rate, but its genetic determinants have not been fully identified. In this feasibility study, we aimed to elucidate the transcriptome profile of AAA and further rev
Externí odkaz:
https://doaj.org/article/304383fe7c9440248d095bc2fba5bc3c
Autor:
Ying Huang, Xin Huang, Xuming Zhou, Jialin Wang, Ruidong Zhang, Futong Ma, Kaiqiang Wang, Zhuoxing Zhang, Xiaoling Dai, Xueying Cao, Chao Zhang, Keke Han, Qian Ren
Publikováno v:
Open Biology, Vol 10, Iss 9 (2020)
Genomic regions with repeated sequences are unstable and prone to rapid DNA diversification. However, the role of tandem repeats within the coding region is not fully characterized. Here, we have identified a new hypervariable C-type lectin gene fami
Externí odkaz:
https://doaj.org/article/a92a4c62fed046589bab6d0042809995
Autor:
Ting-Yuan Liu, Yu-Chia Chen, Yuh-Jyh Jong, Huai-Jen Tsai, Chien-Chin Lee, Ya-Sian Chang, Jan-Gowth Chang, Yung-Fu Chang
Publikováno v:
Open Biology, Vol 7, Iss 1 (2017)
Heterogeneous ribonucleoprotein A1 (hnRNP A1) is crucial for regulating alternative splicing. Its integrated function within an organism has not, however, been identified. We generated hnRNP A1 knockout mice to study the role of hnRNP A1 in vivo. The
Externí odkaz:
https://doaj.org/article/4db5109a0b0b4bcf9348f135e225ddfc
Publikováno v:
Open Biology, Vol 5, Iss 8 (2015)
Vertebrate NCoR-family co-repressors play central roles in the timing of embryo and stem cell differentiation by repressing the activity of a range of transcription factors. They interact with nuclear receptors using short linear motifs (SLiMs) terme
Externí odkaz:
https://doaj.org/article/0810c417bcfe45748aa1e9f30d3d40ea
Publikováno v:
Open Biology, Vol 2, Iss 10 (2012)
Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstr
Externí odkaz:
https://doaj.org/article/128fca20cc5b404fbe5c7069398f15f6