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Publikováno v:
Chinese Medical Journal, Vol 131, Iss 19, Pp 2320-2331 (2018)
Background: XB130 is a recently discovered adaptor protein that is highly expressed in many malignant tumors, but few studies have investigated its role in hepatocellular carcinoma (HCC). Therefore, this study explored the relationship between this p
Externí odkaz:
https://doaj.org/article/f670b31898024e93a5daf51e1dde9e59
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 8, Pp 950-955 (2018)
Background: Oxidized low-density lipoprotein (ox-LDL)-induced oxidative stress and endothelial apoptosis are essential for atherosclerosis. Our previous study has shown that ox-LDL-induced apoptosis is mediated by the protein kinase RNA-like endoplas
Externí odkaz:
https://doaj.org/article/7274557a73c04b9093bcbbbed9c9af71
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 20, Pp 2461-2473 (2018)
Background: Fine particulate matter (PM2.5) exacerbates airway inflammation and hyperreactivity in patients with asthma, but the mechanism remains unclear. The aim of this study was to observe the effects of prolonged exposure to high concentrations
Externí odkaz:
https://doaj.org/article/161db84377394b6f8386ab9faf27d304
Autor:
Ying-Chen Xu, Jing Cui, Li-Jun Zhang, Dong-Xin Zhang, Bing-Chen Xing, Xiong-Wei-Ye Huang, Ji-Xiang Wu, Chao-Jie Liang, Guang-Ming Li
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 1, Pp 82-87 (2018)
Background: Decoy receptor 3 (DcR3) is a protein with anti-apoptotic effect that belongs to the tumor necrosis factor receptor superfamily. DcR3 is highly expressed in a variety of malignant tumors including cholangiocarcinoma and its expression was
Externí odkaz:
https://doaj.org/article/185d4a50b4fb43e8a6b68fa5212834a7
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 23, Pp 2836-2843 (2018)
Background: The demonstrated role of mitogen-activated protein kinase (MAPK) in both cell apoptosis and the inflammation pathway makes it an attractive target for photoreceptor protection. The aim of this study was to investigate the protective effec
Externí odkaz:
https://doaj.org/article/a2d5898a38ea4c43887d8b2446ee7ef7
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 17, Pp 2097-2104 (2018)
Background: Signal transducer and activator of transcription 3 (STAT3) was strongly expressed and activated in psoriatic keratinocytes (KCs) and correlated with the severity of psoriasis. The study aimed to investigate the effects of STAT3 small inte
Externí odkaz:
https://doaj.org/article/676954fcfa0748be8c3f6bae7c99e00b
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 16, Pp 1909-1916 (2018)
Background: MicroRNAs (miRNAs) have been extensively studied over the decades and have been identified as potential molecular targets for cancer therapy. To date, many miRNAs have been found participating in the tumorigenesis of non-small cell lung c
Externí odkaz:
https://doaj.org/article/3c7d0ba0f723448795b132892aee1ee9
Autor:
Cheng-Cheng Song, Quan Hong, Xiao-Dong Geng, Xu Wang, Shu-Qiang Wang, Shao-Yuan Cui, Man-Di Guo, Ou Li, Guang-Yan Cai, Xiang-Mei Chen, Di Wu
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 22, Pp 2666-2675 (2018)
Background: Focal segmental glomerulosclerosis (FSGS) is a kidney disease that is commonly associated with proteinuria and the progressive loss of renal function, which is characterized by podocyte injury and the depletion and collapse of glomerular
Externí odkaz:
https://doaj.org/article/b569ae70bc7a42ba9b1727afc520c30a
Publikováno v:
Chinese Medical Journal, Vol 130, Iss 18, Pp 2205-2214 (2017)
Background: PM2.5 (aerodynamic diameter ≤ 2.5 μm) is a dominant and ubiquitous air pollutant that has become a global concern as PM2.5 exposure has been linked to many adverse health effects including cardiovascular and pulmonary diseases. Emergin
Externí odkaz:
https://doaj.org/article/30bb87a1710443e98413d086ba69f68d
Publikováno v:
Chinese Medical Journal, Vol 130, Iss 19, Pp 2302-2306 (2017)
Background: Olfactory disorder is an early manifestation of Parkinson's disease (PD), likely to be associated with abnormalities of the dopaminergic neurons in the olfactory bulb (OB); however, the causes of olfactory disorder in PD are not entirely
Externí odkaz:
https://doaj.org/article/b30ebac1a3be4044b2a72fcf99920587