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Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 3-21 (2024)
This review conteins updated information on the structure, localization and regulation of phosphatidic acid (PA)-producing enzymes phospholipase D, phosphoinositide-specific and non-specific phospholipases C and diacylglycerol kinases is analyzed. Th
Externí odkaz:
https://doaj.org/article/8b565343922e440e9d0a71bcc8d1d214
Autor:
V. L. Bilous, A. O. Tykhomyrov
Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 37-48 (2024)
Prolonged inflammation and excessive neovascularization of the cornea due to severe injury can impair optical clarity and lead to vision impairment. Plasminogen kringle (K) fragments, known as angiostatins (AS), play a well-established role as inhibi
Externí odkaz:
https://doaj.org/article/ac8aac13fad1452088611d36ce59649d
Autor:
Т. О. Veklich, О. V. Bevza, О. V. Maliuk, S. О. Kosterin, R. V. Rodik, S. H. Vyshnevskyi, V. І. Kalchenko
Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 22-36 (2024)
The experiments with the suspension of plasma membranes of myometrium cells, treated with 0.1% digitonin solution, were used to study kinetic regularities of the inhibitory effect of tetra-N-phenylsulfonyl trifluoroacetamidine-thiacalixarene (С-1087
Externí odkaz:
https://doaj.org/article/d684707c356e47849f16f4811671b7a7
Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 60-72 (2024)
Fetuin-A, a plasma glycoprotein, has been demonstrated to play an essential role in the pathogenesis of several metabolic disorders. This study aimed to estimate fetuin-A serum level in patients with newly diagnosed primary hyperthyroidism (PHT) an
Externí odkaz:
https://doaj.org/article/01510ad0273f44ddb55fbf302402dc7d
Autor:
M. Mithun, V. Rajashekaraiah
Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 49-59 (2024)
Drug-induced thrombocytopenia (DIT) is a disorder where platelet count declines as an adverse effect of therapeutic drugs. Plant extract of C. papaya Caripill™ is known to elevate platelet count under thrombocytopenic conditions. To evaluate the co
Externí odkaz:
https://doaj.org/article/4987c2921bd844b1ac438f05dc91536b
Autor:
M. Lootsik, V. Antonyuk, I. Ivasechko, N. Skorokhyd, H. Kosiakova, O. Mehed’, T. Horid’ko, N. Hula, O. Klyuchivska, R. Panchuk, N. Pokhodylo, О. Barabash, T. Dumych, R. Stoika
Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 80-95 (2024)
Creation of novel remedies efficient in supporting wound healing remains an actual task in pharmacology. Hydrogels showed high efficiency in wound healing and tissue regeneration due to viscosity, elasticity and fluidity that provide them with functi
Externí odkaz:
https://doaj.org/article/13255d3bed5a4b63a7c024fd7f211976
Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 96-102 (2024)
We have previously shown that Bacillus sp. IMV B-7883 exhibits both elastase and fibrinogenolytic activity. One of the approaches to enhance enzymatic activity is the use of coordination compounds capable to affect enzyme’s activity or synthesis. T
Externí odkaz:
https://doaj.org/article/b178c615f9e14a2d99c124ca23ca413a
Publikováno v:
The Ukrainian Biochemical Journal, Vol 96, Iss 1, Pp 73-79 (2024)
Diethyl phthalate (DEF) is a synthetic chemical widely used as plasticizer and additive in personal care and pharmaceutical products. Low-dose exposure to this xenobiotic over a long period contributes to its intake into the human body in a high dose
Externí odkaz:
https://doaj.org/article/142d4c02cc6d43f6909bcf43a1b2d0a1
Autor:
Т. О. Veklich, R. V. Rodik, О. V. Tsymbalyuk, О. V. Shkrabak, O.V. Maliuk, S. O. Karakhim, S. H. Vyshnevskyi, V. І. Kalchenko, S. O. Kosterin
Publikováno v:
The Ukrainian Biochemical Journal, Vol 95, Iss 6, Pp 5-20 (2023)
The enzymatic and kinetic analyses were used to demonstrate that 5,11,17,23-tetra(trifluoro)methyl(phenylsulfonylimino)methylamino-25,27-dihexyloxy-26,28-dihydroxythiacalix[4]arene С-1087 effectively inhibited the Са2+,Mg2+-АТРase activity of t
Externí odkaz:
https://doaj.org/article/daa177ce07ae437db86ab33db57e8398
Publikováno v:
The Ukrainian Biochemical Journal, Vol 95, Iss 6, Pp 21-29 (2023)
One of the primary mechanisms of retinal neurodegeneration in diabetes mellitus is gamma-aminobutyric acid (GABA) deficiency that makes the use of GABA-benzodiazepine receptor modulators a promising option for the correction of this diabetic complica
Externí odkaz:
https://doaj.org/article/f43b59ff7be04720b770c525b88bdecc