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of 45
pro vyhledávání: ''
Autor:
Nuanyi Liang, Kwangsik Nho, John W. Newman, Matthias Arnold, Kevin Huynh, Peter J. Meikle, Kamil Borkowski, Rima Kaddurah-Daouk, the Alzheimer’s Disease Metabolomics Consortium
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Inflammation is an important factor in Alzheimer’s disease (AD). An NMR measurement in plasma, glycoprotein acetyls (GlycA), captures the overall level of protein production and glycosylation implicated in systemic inflammation. With its a
Externí odkaz:
https://doaj.org/article/1fa1238cbe3847c59f63509c071de317
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Anticancer drugs may affect the incidence of dementia by modulating the common pathophysiology between cancer and dementia. However, there is a paucity of research that focused on anticancer drugs with different mechanisms of action and thei
Externí odkaz:
https://doaj.org/article/1240b1a4989e40babe89c6d0904f0b4e
Autor:
Xinyi Wu, Mingyu Liu, Xinyue Zhang, Xue Pan, Xiaotong Cui, Jiahui Jin, Huanan Sun, Chuyu Xiao, Xiangyi Tong, Liou Ren, Yaxuan Wang, Xuezhao Cao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract In this study, we conducted an in-depth exploration of Alzheimer's Disease (AD) by integrating state-of-the-art methodologies, including single-cell RNA sequencing (scRNA-seq), weighted gene co-expression network analysis (WGCNA), and a conv
Externí odkaz:
https://doaj.org/article/b3f66d6748d0496ca57de8349c1d0f29
Autor:
Richa Aishwarya, Chowdhury S. Abdullah, Naznin Sultana Remex, Mohammad Alfrad Nobel Bhuiyan, Xiao-Hong Lu, Nirav Dhanesha, Karen Y. Stokes, A. Wayne Orr, Christopher G. Kevil, Md. Shenuarin Bhuiyan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer's Disease (AD) is a progressive neurodegenerative disease caused by the deposition of Aβ aggregates or neurofibrillary tangles. AD patients are primarily diagnosed with the concurrent development of several cardiovascular dysfunct
Externí odkaz:
https://doaj.org/article/48fd05b784bd4ac59164a45065a5bc38
Autor:
Paul Trlin, Jenny Gong, Katie K. N. Tran, Vickie H. Y. Wong, Pei Ying Lee, Anh Hoang, Da Zhao, Leah C. Beauchamp, Jeremiah K. H. Lim, Andrew Metha, Kevin J. Barnham, David I. Finkelstein, Bang V. Bui, Phillip Bedggood, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s disease is another neurodegenerative disease where brain pathobiology such as alpha-synuclein and iron over
Externí odkaz:
https://doaj.org/article/4922d8416bbd4e5ca8336a9df43afadf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The relationship between the triglyceride glucose-body mass index (TyG-BMI) index and Alzheimer’s disease (AD) pathology, cognition, and brain structure remains unclear. This study aimed to investigate these associations, focusing on cereb
Externí odkaz:
https://doaj.org/article/ec75c3c69d044b5cb85fd23f5a6aadf7
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-25 (2024)
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized primarily by cognitive impairment. The motivation of this paper is to explore the impact of the visual information transmission pathway (V–H pathway) on AD, and the fol
Externí odkaz:
https://doaj.org/article/009c46554fc94012af577bd9e8f78af7
Autor:
Forough Radfar, Mehdi Shahbazi, Shahzad Tahmasebi Boroujeni, Elahe Arab Ameri, Maryam Farahmandfar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer's disease (AD) is a neurological condition that is connected with a decline in a person's memory as well as their cognitive ability. One of the key topics of AD research has been the exploration of metabolic causes. We investigated
Externí odkaz:
https://doaj.org/article/adb6e2f828bf4ea2905972154cbdcea8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD), the predominant form of dementia, is a growing global challenge, emphasizing the urgent need for accurate and early diagnosis. Current clinical diagnoses rely on radiologist expert interpretation, which is prone t
Externí odkaz:
https://doaj.org/article/5d875717374a4001a9143e60223672d0
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Understanding the exact pathophysiological mechanisms underlying the involvement of triggering receptor expressed on myeloid cells 2 (TREM2) related microglia activation is crucial for the development of clinical trials targeting microglia a
Externí odkaz:
https://doaj.org/article/19569c4b0ad94b9f83ae39c014d28a53