Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jensen, A"'
Autor:
Andrey Höglund, Rie Henriksen, Allison M Churcher, Carlos M Guerrero-Bosagna, Alvaro Martinez-Barrio, Martin Johnsson, Per Jensen, Dominic Wright
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1010719 (2024)
DNA methylation is a key regulator of eukaryote genomes, and is of particular relevance in the regulation of gene expression on the sex chromosomes, with a key role in dosage compensation in mammalian XY systems. In the case of birds, dosage compensa
Externí odkaz:
https://doaj.org/article/8e0367e0a1834a1e8cd831ae52e1ba77
Autor:
Christopher J Adams, Mitchell Conery, Benjamin J Auerbach, Shane T Jensen, Iain Mathieson, Benjamin F Voight
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010807 (2023)
Germline mutation is the mechanism by which genetic variation in a population is created. Inferences derived from mutation rate models are fundamental to many population genetics methods. Previous models have demonstrated that nucleotides flanking po
Externí odkaz:
https://doaj.org/article/46701a5fce6b4e619ee0f573d01e5c25
Autor:
Fabian Freund, Elise Kerdoncuff, Sebastian Matuszewski, Marguerite Lapierre, Marcel Hildebrandt, Jeffrey D Jensen, Luca Ferretti, Amaury Lambert, Timothy B Sackton, Guillaume Achaz
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010677 (2023)
The standard neutral model of molecular evolution has traditionally been used as the null model for population genomics. We gathered a collection of 45 genome-wide site frequency spectra from a diverse set of species, most of which display an excess
Externí odkaz:
https://doaj.org/article/ccb0b82497cf45238c957dfd688c8606
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010022 (2022)
The ability to accurately identify and quantify genetic signatures associated with soft selective sweeps based on patterns of nucleotide variation has remained controversial. We here provide counter viewpoints to recent publications in PLOS Genetics
Externí odkaz:
https://doaj.org/article/8489a67dd3ff4b6e99aadea321c8896e
Autor:
Lucilla Pizzo, Micaela Lasser, Tanzeen Yusuff, Matthew Jensen, Phoebe Ingraham, Emily Huber, Mayanglambam Dhruba Singh, Connor Monahan, Janani Iyer, Inshya Desai, Siddharth Karthikeyan, Dagny J Gould, Sneha Yennawar, Alexis T Weiner, Vijay Kumar Pounraja, Arjun Krishnan, Melissa M Rolls, Laura Anne Lowery, Santhosh Girirajan
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009112 (2021)
We previously identified a deletion on chromosome 16p12.1 that is mostly inherited and associated with multiple neurodevelopmental outcomes, where severely affected probands carried an excess of rare pathogenic variants compared to mildly affected ca
Externí odkaz:
https://doaj.org/article/ea88765e5dca40999d37fc1d27f96ec3
Autor:
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007345 (2018)
[This corrects the article DOI: 10.1371/journal.pgen.1006728.].
Externí odkaz:
https://doaj.org/article/213e0f9e85ad4187b8637136ca905e08
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1006999 (2017)
During its life cycle, Caulobacter crescentus undergoes a series of coordinated shape changes, including generation of a polar stalk and reshaping of the cell envelope to produce new daughter cells through the process of cytokinesis. The mechanisms b
Externí odkaz:
https://doaj.org/article/72cee4633bca4b32b9bd57ca3a6a11a4
Autor:
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006728 (2017)
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify
Externí odkaz:
https://doaj.org/article/3532e4699b9641beb8d3163da545010d
Autor:
Carolyn G Marsden, Ryan B Jensen, Jennifer Zagelbaum, Eli Rothenberg, Scott W Morrical, Susan S Wallace, Joann B Sweasy
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006208 (2016)
The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we report on a novel human RAD51 variant found in an aggressive and therapy-refractive breast carci
Externí odkaz:
https://doaj.org/article/862a410adb6e4d8390160c03ec59b5dd
Autor:
Yuehan Wu, Suk-Hee Lee, Elizabeth A Williamson, Brian L Reinert, Ju Hwan Cho, Fen Xia, Aruna Shanker Jaiswal, Gayathri Srinivasan, Bhavita Patel, Alexis Brantley, Daohong Zhou, Lijian Shao, Rupak Pathak, Martin Hauer-Jensen, Sudha Singh, Kimi Kong, Xaiohua Wu, Hyun-Suk Kim, Timothy Beissbarth, Jochen Gaedcke, Sandeep Burma, Jac A Nickoloff, Robert A Hromas
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005675 (2015)
Replication fork stalling and collapse is a major source of genome instability leading to neoplastic transformation or cell death. Such stressed replication forks can be conservatively repaired and restarted using homologous recombination (HR) or non
Externí odkaz:
https://doaj.org/article/95fc9886b9814bed88fac687edfe81e9