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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aimsRecent studies suggest that empagliflozin reduces total and cardiovascular mortality in both diabetic and nondiabetic subjects. Although the exact mechanism is unclear, it is understood to positively affect myocardial energetics, i
Externí odkaz:
https://doaj.org/article/fa2238b0f7a646cf9584cc6424377b21
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Excessive alcohol intake often results in hangovers and inflammatory liver damage, posing a significant health concern. Current treatment options for hangovers are still insufficient, highlighting the urgent need for new therapeutic app
Externí odkaz:
https://doaj.org/article/08fdc7fed3d140f1bbee0cc1e6ad9631
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundOsteoarthritis (OA) is a chronic degenerative disease mainly characterized by cartilage damage and synovial inflammation. Si Miao Powder, an herbal formula, was recorded in ancient Chinese medicine prescription with excellent anti-inflammat
Externí odkaz:
https://doaj.org/article/d38b805415514c3fb04ef838529fb353
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Heart failure (HF) is a chronic condition that progressively worsens and continues to be a major financial burden and public health concern. The “gut-heart” axis provides an innovative perspective and therapeutic strategy for preventing and treat
Externí odkaz:
https://doaj.org/article/ecdc29d684ca46449f9202ab2d7f1e2c
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/d5e5634dfb1b43e783b9a4ac91336b0e
Autor:
Stefania Petrosino, Marika Cordaro, Roberta Verde, Aniello Schiano Moriello, Gabriele Marcolongo, Carlo Schievano, Rosalba Siracusa, Fabiana Piscitelli, Alessio F. Peritore, Rosalia Crupi, Daniela Impellizzeri, Emanuela Esposito, Salvatore Cuzzocrea, Vincenzo Di Marzo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/afffa4ff490d488e94a32ae49e6ab046
Autor:
Anne Barbot, Michele Lheritier-Barrand, Margarita Murrieta-Aguttes, Maud Leonetti, Jimmy Vernaz, Song Huang, Samuel Constant, Bernadett Boda
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundFexofenadine (FEX) is an antihistamine that acts as an inverse agonist against histamine (HIS) receptor 1 (H1R), which mediates the allergic reaction. Inverse agonists may be more potent than neutral antagonists, as they bind the same recep
Externí odkaz:
https://doaj.org/article/bddee3585c6b4a33a79daa6356106c97
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Phosphodiesterase 4 (PDE4) inhibitors are effective therapeutic agents for various inflammatory diseases. Roflumilast, apremilast, and crisaborole have been developed and approved for the treatment of chronic obstructive pulmonary disease psoriatic a
Externí odkaz:
https://doaj.org/article/2866748cc8b74981aece5fa644aab5ad
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Artemisinin, artemether, artesunate, and dihydroartemisinin are renowned for their antimalarial potential. The current study aims to repurpose the above-mentioned artemisinic compounds (ACs) by conducting an intercomparison to evaluate their antiinfl
Externí odkaz:
https://doaj.org/article/e0f7fc9f28e146a89d7af95777dbfc8f
Autor:
Shouyi Liu, Bo Zhang, Jingqun Zhou, Jianfeng Lv, Jinxia Zhang, Xiangyan Li, Weihua Yang, Yuanlin Guo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The clinical efficacy of adrenergic β-receptor (β-AR) blockers in significantly stabilizing atherosclerotic plaques has been extensively supported by evidence-based medical research; however, the underlying mechanism remains unclear. Recent finding
Externí odkaz:
https://doaj.org/article/8d01a5979ca74d83b6589e667b35cb22