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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Adiponectin is a pleiotropic cytokine predominantly derived from adipose tissue. In addition to its role in regulating energy metabolism, adiponectin may also be related to estrogen-dependent diseases, and many studies have confirmed its involvement
Externí odkaz:
https://doaj.org/article/9af73d5e528c4168a2e1217f335b4455
Autor:
Diana V. Ávila-Martínez, Wendy K. Mixtega-Ruiz, José M. Hurtado-Capetillo, Oscar Lopez-Franco, Mónica Flores-Muñoz
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The renin-angiotensin system (RAS) is an important cascade of enzymes and peptides that regulates blood pressure, volume, and electrolytes. Within this complex system of reactions, its counter-regulatory axis has attracted attention, which has been a
Externí odkaz:
https://doaj.org/article/ff4d1b30f2b849b69f334559a797d12f
Autor:
Fei-Fei Gao, Dian-Qing Chen, Yue-Tong Jiang, Cui-Fei Han, Bi-Yun Lin, Zhan Yang, Juan-Hua Quan, Ying-Huan Xiong, Xin-Tian Chen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Lung injury leads to respiratory dysfunction, low quality of life, and even life-threatening conditions. Circular RNAs (circRNAs) are endogenous RNAs produced by selective RNA splicing. Studies have reported their involvement in the progression of lu
Externí odkaz:
https://doaj.org/article/cfc789a00f3b4e34abafd4193ba5b0e8
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Myocardial infarction (MI) imposes a huge medical and economic burden on society, and cardiac repair after MI involves a complex series of processes. Understanding the key mechanisms (such as apoptosis, autophagy, inflammation, and fibrosis) will fac
Externí odkaz:
https://doaj.org/article/a5c20d2d8c3f4bdfb8c7074b4dacaeaf
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Objectives: Non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) and hepatocarcinoma is a serious and growing problem. However, the development of new therapies is severely hindered by a lack of high-t
Externí odkaz:
https://doaj.org/article/dca278fd60ba4901964c68bc8ba6004c
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Immune cells are essential for initiating and developing the fibrotic process by releasing cytokines and growth factors that activate fibroblasts and promote extracellular matrix deposition. Immunometabolism describes how metabolic alterations affect
Externí odkaz:
https://doaj.org/article/80aa5988ae914adb9fb77439d6584126
Autor:
Mengmeng Ma, Tianping Bao, Jingyan Li, Linxia Cao, Bingrui Yu, Jingjing Hu, Huaiping Cheng, Zhaofang Tian
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Objective: Bronchopulmonary dysplasia (BPD) is a common complication of prematurity and has no specific treatment option. Moreover, inflammation and fibrosis play a vital role in the development of BPD. Thus, this study aimed to explore the role of t
Externí odkaz:
https://doaj.org/article/53f86e03d8b9452ca57348e870bc281d
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Acute respiratory distress syndrome (ARDS) is the most common respiratory disease in ICU. Although there are many treatment and support methods, the mortality rate is still high. The main pathological feature of ARDS is the damage of pulmonary microv
Externí odkaz:
https://doaj.org/article/21c2239839774493ae5ee4741078861e
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Immune checkpoint inhibitors (ICIs), including cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), and its ligand 1 (PD-L1), have improved the survival in multiple types of cancers; however, ICIs may cause cardiovascular toxici
Externí odkaz:
https://doaj.org/article/2da40865744848dfb7946b4b40e4610b
Autor:
Chunkun Yang, Qingquan Pan, Kui Ji, Zhuang Tian, Hongyuan Zhou, Shuanghong Li, Chuanchao Luo, Jun Li
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Cardiovascular disease is a global health problem. Astragaloside IV (AS-IV) is a saponin compound extracted from the roots of the Chinese herb Astragalus. Over the past few decades, AS-IV has been shown to possess various pharmacological properties.
Externí odkaz:
https://doaj.org/article/992e92cfc07241ba92ddc3e1bfa3345c