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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450). Esterified AA is hydrolysed by phospholipase A2 into a free form that
Externí odkaz:
https://doaj.org/article/f9900b6d2492448882bedc4e2ce8965d
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Renal fibrosis is increasingly recognized as a global public health problem. Acute kidney injury (AKI) and chronic kidney disease (CKD) both result in renal fibrosis. Oxidative stress and inflammation play central roles in progressive renal fibrosis.
Externí odkaz:
https://doaj.org/article/d868712f4bb941fdad2bb66b12b1baf2
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: The incidence of ischemic stroke (IS) is much higher among patients with chronic kidney disease (CKD) compared to the general population. Few studies have evaluated the association between the risk of IS and the use of Chinese herbal medi
Externí odkaz:
https://doaj.org/article/8466f28127cf46eabaaaca182945a048
Autor:
Lucas Opazo-Ríos, Antonio Tejera-Muñoz, Manuel Soto Catalan, Vanessa Marchant, Carolina Lavoz, Sebastián Mas Fontao, Juan Antonio Moreno, Marta Fierro Fernandez, Ricardo Ramos, Beatriz Suarez-Alvarez, Carlos López-Larrea, Marta Ruiz-Ortega, Jesús Egido, Raúl R. Rodrigues-Díez
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide. Although remarkable therapeutic advances have been made during the last few years, there still exists a high residual risk of disease progression to end-stage re
Externí odkaz:
https://doaj.org/article/1da83a47d26d4589802051a891591700
Autor:
Yinghui Wang, Lu Gao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chronic kidney disease (CKD) and cardiac insufficiency often co-exist, particularly in uremic patients on hemodialysis (HD). The occurrence of abnormal renal function in patients with cardiac insufficiency is often indicative of a poor prognosis. It
Externí odkaz:
https://doaj.org/article/bad59bfbbbbe4971bc97beae95b999b7
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic heart failure (HF) frequently causes progressive decline in kidney function, known as cardiorenal syndrome-2 (CRS2). Current treatment options for CRS2 remain unacceptably limited. Trimethylamine-N-oxide (TMAO), a metabolite of gut microbiota
Externí odkaz:
https://doaj.org/article/b2385409166d4bb79f3a41d196ce7450
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic kidney disease (CKD) is an increasing global public health problem, with high morbidity and mortality. Jian-Pi-Yi-Shen (JPYS) formula is a representative traditional Chinese medicine formula in the treatment of CKD, which is widely used in cl
Externí odkaz:
https://doaj.org/article/5cf1d3fd23e74142af936a323e40cea8
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/e997c788e23c4a6eb6801f5a0c60c818
Autor:
Stefanny M. Figueroa, Mauricio Lozano, Carolina Lobos, Matthew T. Hennrikus, Alexis A. Gonzalez, Cristián A. Amador
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Chronic kidney disease (CKD) is characterized by renal dysfunction, which is a common feature of other major diseases, such as hypertension and diabetes. Unilateral ureteral obstruction (UUO) has been used as a model of CKD in experimental animals an
Externí odkaz:
https://doaj.org/article/8a9aed299bc84183ac2f987851132ff5
Autor:
Jose Luis Morgado-Pascual, Sandra Rayego-Mateos, Lucia Tejedor, Beatriz Suarez-Alvarez, Marta Ruiz-Ortega
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Epigenetic mechanisms, especially DNA methylation and histone modifications, are dynamic processes that regulate the gene expression transcriptional program in normal and diseased states. The bromodomain and extraterminal (BET) protein family (BRD2,
Externí odkaz:
https://doaj.org/article/1f2e23b36bcd4ba586f37da784360fff