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Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/9b26e613c0b846728ee3f9cc3771e253
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Breast cancer is one of the most common malignancies and the leading cause of cancer-related death in women. HER2 overexpression is a factor for poor prognosis in breast cancer, and anti-HER2 therapy improves survival in these patients. A dual-target
Externí odkaz:
https://doaj.org/article/9e5913302a3c4cfd8d82770d1dd162c3
Autor:
Federica Martorana, Gianmarco Motta, Giuliana Pavone, Lucia Motta, Stefania Stella, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism. Deregulation of this pathway is a common event in breast cancer including h
Externí odkaz:
https://doaj.org/article/3e62123234b6441682d4dde9eb7d7a0b
Autor:
Anusha Ande, Tanaya R. Vaidya, Bao N. Tran, Michael Vicchiarelli, Ashley N. Brown, Sihem Ait-Oudhia
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background: Emergence of Human epidermal growth factor receptor 2 (HER2) therapy resistance in HER2-positive (HER2+) breast cancer (BC) poses a major clinical challenge. Mechanisms of resistance include the over-activation of the PI3K/mTOR and Src pa
Externí odkaz:
https://doaj.org/article/1a6dd700031345f0ae84cef24ea7a1b6
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Accumulating evidences have suggested the existence of breast cancer stem cells (BCSCs), which possess the potential of both self-renewal and differentiation. The origin of BCSCs might have relationship to the development of normal mammary stem cells
Externí odkaz:
https://doaj.org/article/f49d3d3a5f0a41dd9e9e3168e44399d1