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Autor:
Nusrat Jan, Shazia Sofi, Adel Abo Mansoor, Adil Abdelrahim, Irshad Ahmad, Abdullah Almilabairy, Fuzail Ahmad, Manzoor Ahmad Mir
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThe members retinoic acid receptors (RARs) (α, β, and γ) and retinoid X receptors (RXRs) (α, β, and γ) belong to the retinoid receptor family. They regulate the biological action of classical retinoids through nuclear retinoid recep
Externí odkaz:
https://doaj.org/article/cce449628de94fa5926ed4c77949c867
Autor:
Joelle Mesmar, Rola Abdallah, Kamar Hamade, Serine Baydoun, Najlaa Al-Thani, Abdullah Shaito, Marc Maresca, Adnan Badran, Elias Baydoun
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Breast cancer (BC) is the second most common cancer overall. In women, BC is the most prevalent cancer and the leading cause of cancer-related mortality. Triple-negative BC (TNBC) is the most aggressive BC, being resistant to hormonal and
Externí odkaz:
https://doaj.org/article/315088d7bf7746a9a9b700338e8e0f78
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Breast cancer is the second leading cancer among all types of cancers. It accounts for 12% of the total cases of cancers. The complex and heterogeneous nature of breast cancer makes it difficult to treat in advanced stages. The expression of various
Externí odkaz:
https://doaj.org/article/75eea3b60a0f4cc6823722f7fe3156f5
Autor:
Garcia-Lazaro Rocio Soledad, Caligiuri Lorena Gisel, Lorenzo Norailys, Lamdan Humberto, Alonso Daniel Fernando, Farina Hernan Gabriel
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell
Externí odkaz:
https://doaj.org/article/a7ac6fdea3374455a3103b2cd23ca7f2
Autor:
Xin An, Xi Lin, Anli Yang, Qiwei Jiang, Bingchuan Geng, Mayan Huang, Jiabin Lu, Zhicheng Xiang, Zhongyu Yuan, Shusen Wang, Yanxia Shi, Hua Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
ObjectiveCavin3 is a putative tumor suppressor protein. However, its molecular action on tumor regulation is largely unknown. The aim of the current study is to explore the implication of cavin3 alteration, its clinical significance, and any potentia
Externí odkaz:
https://doaj.org/article/058443e881c0462c9cad3b7b37dcea7a
Autor:
Qianxuan Luo, Ting Wu, Wenfang Wu, Gong Chen, Xuan Luo, Liping Jiang, Huai Tao, Mingqiang Rong, Shuntong Kang, Meichun Deng
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are involved in the metastatic process of invasion and migration. Nav1.5 is a
Externí odkaz:
https://doaj.org/article/e1aa7e132c6f4c21a0eefed7c2c3e3e1
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
ObjectiveThe aim of this study is to investigate the anti-cancer activity and sensibilization of baicalin (BA) against breast cancer (BC) cells.MethodsThe anti-proliferation of BA in BC cell lines was evaluated by MTT and colony formation assays. Apo
Externí odkaz:
https://doaj.org/article/648640d7a9a44e1bb1250c4daecfa943
Autor:
Yali Li, Cailing Gan, Yange Zhang, Yan Yu, Chen Fan, Yuanle Deng, Qianyu Zhang, Xi Yu, Yiwen Zhang, Liqun Wang, Fang He, Yongmei Xie, Tinghong Ye, Wenya Yin
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: Breast cancer is the most common female cancer with considerable metastatic potential, which urges the need for developing novel potential drug candidate to inhibit tumor metastasis. Signal transducer and activator of transcription 3 (Sta
Externí odkaz:
https://doaj.org/article/e8a7a2bf20d24252b17e6c8ff338dca8
Autor:
Yanhong Pan, Qian Zheng, Wenting Ni, Zhonghong Wei, Suyun Yu, Qi Jia, Meng Wang, Aiyun Wang, Wenxing Chen, Yin Lu
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Aerobic glycolysis plays a decisive role in cancer growth. However, its role in cancer metastasis was rarely understood. Cantharidin a natural compound from an arthropod insect cantharis exerts potent anticancer activity. Here we found cantharidin po
Externí odkaz:
https://doaj.org/article/995e838dd63748e084c26a55afaaa19e
Autor:
Muthu K. Shanmugam, Kwang Seok Ahn, Annie Hsu, Chern Chiuh Woo, Yi Yuan, Kwong Huat Benny Tan, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Angele Pei Fern Koh, Frank Arfuso, Ruby Yun-Ju Huang, Lina H. K. Lim, Gautam Sethi, Alan Prem Kumar
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in patients with breast cancer. Therefore, new agents that can abrogate C
Externí odkaz:
https://doaj.org/article/b215012bc4f64c1e873510fa61002aeb