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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThis study aimed to assess the cost-effectiveness of combining utidelone with capecitabine, compared to capecitabine monotherapy, for the treatment of anthracycline- and taxane-refractory metastatic breast cancer within the Chinese healthca
Externí odkaz:
https://doaj.org/article/dee1e324d4a9483eaf9d1fcfe77470ff
Autor:
Yalan Yan, Sijie Li, Lanqian Su, Xinrui Tang, Xiaoyan Chen, Xiang Gu, Guanhu Yang, Hao Chi, Shangke Huang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Breast cancer, due to resistance to standard therapies such as endocrine therapy, anti-HER2 therapy and chemotherapy, continues to pose a major health challenge. A growing body of research emphasizes the heterogeneity and plasticity of metabolism in
Externí odkaz:
https://doaj.org/article/6c38e4fa446f4a4c85e9ddcd8b7749fe
Autor:
Sukanya B. Jadhav, Michaela Vondrackova, Petra Potomova, Cristian Sandoval-Acuña, Jana Smigova, Kristyna Klanicova, Daniel Rosel, Jan Brabek, Jan Stursa, Lukas Werner, Jaroslav Truksa
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Multiple studies indicate that iron chelators enhance their anti-cancer properties by inducing NDRG1, a known tumor and metastasis suppressor. However, the exact role of NDRG1 remains controversial, as newer studies have shown that NDRG1 can also act
Externí odkaz:
https://doaj.org/article/babf7f9ee7ce45d2aa4ee3ab2d7ec896
Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/09a3639dbb854124948ce469bf13e324
Autor:
Deena Elsori, Pratibha Pandey, Seema Ramniwas, Rahul Kumar, Sorabh Lakhanpal, Safia Obaidur Rab, Samra Siddiqui, Ajay Singh, Mohd Saeed, Fahad Khan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The bioactive compounds present in citrus fruits are gaining broader acceptance in oncology. Numerous studies have deciphered naringenin’s antioxidant and anticancer potential in human and animal studies. Naringenin (NGE) potentially suppresses can
Externí odkaz:
https://doaj.org/article/1dc2e58459a64791bb71e2fa1c2a6a12
Autor:
Nusrat Jan, Shazia Sofi, Adel Abo Mansoor, Adil Abdelrahim, Irshad Ahmad, Abdullah Almilabairy, Fuzail Ahmad, Manzoor Ahmad Mir
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThe members retinoic acid receptors (RARs) (α, β, and γ) and retinoid X receptors (RXRs) (α, β, and γ) belong to the retinoid receptor family. They regulate the biological action of classical retinoids through nuclear retinoid recep
Externí odkaz:
https://doaj.org/article/cce449628de94fa5926ed4c77949c867
Autor:
Amr Maged, Mostafa Mabrouk, Hanzada T. Nour El-Din, Lamyaa Osama, Shaimaa M. Badr-Eldin, Azza A. Mahmoud
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Breast cancer is among the most prevalent tumors worldwide. In this study, in-situ forming implants (ISFIs) containing rosuvastatin calcium were prepared using three types of poly (D, L-lactic-co-glycolic acid) (PLGA), namely, PLGA 50/50 with ester t
Externí odkaz:
https://doaj.org/article/40934f477e4341cd8e5d313449219e3a
Autor:
Uttara Saran, Balaji Chandrasekaran, Ashish Tyagi, Vaibhav Shukla, Amandeep Singh, Arun K. Sharma, Chendil Damodaran
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/e6f122faf8a5446faaec8a0850cc5089
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveGrowth differentiation factor 15 (GDF-15) is a stress-responsive cytokine that regulates myocardial injury, cardiac overloading pressure, and inflammation and is related to the risk of cardiovascular diseases and events. The current study ai
Externí odkaz:
https://doaj.org/article/1831a1fef86746debd5250605f5c066f
Autor:
Emily M. Esquea, Lorela Ciraku, Riley G. Young, Jessica Merzy, Alexandra N. Talarico, Nusaiba N. Ahmed, Mangalam Karuppiah, Anna Ramesh, Adam Chatoff, Claudia V. Crispim, Adel A. Rashad, Simon Cocklin, Nathaniel W. Snyder, Joris Beld, Nicole L. Simone, Mauricio J. Reginato, Alexej Dick
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rely on the conversion of acetate to acetyl-CoA by the enzyme acetyl-CoA synthetase 2 (ACSS2), a
Externí odkaz:
https://doaj.org/article/4ae2b15c3c5446188251b5c916b863e7