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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Previous studies have explored the median effective concentration (EC50) of ropivacaine for labor epidural analgesia in parturients with obesity. However, the clinical relevance of the 90% effective concentration (EC90) remains unclear. T
Externí odkaz:
https://doaj.org/article/5aedb9820f0a4fa995320b8135784e6d
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
CD10, a zinc-dependent metalloprotease found on the cell surface, plays a pivotal role in an array of physiological and pathological processes including cardiovascular regulation, immune function, fetal development, pain response, oncogenesis, and ag
Externí odkaz:
https://doaj.org/article/efb46c4f4888409ebe6c075336b99ade
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Over 20 million adults and 6 million children in the United States (US) have asthma, a chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and mucus hypersecretion. Obesity, another highly prevalent disease in the U
Externí odkaz:
https://doaj.org/article/35de414a77cd4d218c100117b8ee68c9
Autor:
Yong Rao, Rui Su, Chenyan Wu, Guanyu Yang, Renquan Fu, Junjie Wu, Jinqiang Liang, Jin Liu, Zhongping Jiang, Congjun Xu, Ling Huang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aims: Obesity is one of the most prevalent diseases worldwide with less ideal approved agents in clinic. Activating the HSF1/PGC-1α axis in adipose tissues has been reported to induce thermogenesis in mice, which presents a promising
Externí odkaz:
https://doaj.org/article/17b268bbdeff460c8b87c0c1eec0aad2
Autor:
Islam A. Berdaweel, T. Blake Monroe, Amany A. Alowaisi, Jolonda C. Mahoney, I-Chau Liang, Kaitlyn A. Berns, Dylan Gao, Jared M. McLendon, Ethan J. Anderson
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Oral consumption of histidyl dipeptides such as l-carnosine has been suggested to promote cardiometabolic health, although therapeutic mechanisms remain incompletely understood. We recently reported that oral consumption of a carnosine analog suppres
Externí odkaz:
https://doaj.org/article/809d72afb2f34be3a30a897c93994330
Autor:
Daewon Han, Deokryong Kim, Haeil Kim, Jeonga Lee, Jungmook Lyu, Jong-Seok Kim, Jongdae Shin, Jeong Sig Kim, Do Kyung Kim, Hwan-Woo Park
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Metabolism-associated fatty liver disease (MAFLD) is a global health concern because of its association with obesity, insulin resistance, and other metabolic abnormalities. Methylsulfonylmethane (MSM), an organic sulfur compound found i
Externí odkaz:
https://doaj.org/article/a7804bb2140b414cb99d9a88f818ef78
Autor:
Maria Ponticelli, Laura Hidalgo-García, Patricia Diez-Echave, Teresa Vezza, Miguel Romero, Iñaki Robles-Vera, Juan Duarte, Filomena De Biasio, Domenico Gorgoglione, Ludovica Lela, Julio Galvez, Luigi Milella
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction:Solanum aethiopicum L., commonly known as scarlet eggplant (Solanaceae family) is one of the most traditionally cultivated vegetables in Basilicata, a southern region of Italy. Although multiple uses have been given to this vegetable, da
Externí odkaz:
https://doaj.org/article/f641a4de67664c58beadab756ca8fa62
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ad0cfcfc4f77417d8981dcc7c05a9c62
Autor:
Kyungha Min, Bumjo Oh, Hye Yeon Koo, Yang-Hyun Kim, Ji-Won Lee, Sangsub Lee, Youngah Kim, Hyuktae Kwon
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Glaceum Inc. has proposed HSG4112, a structural analogue of glabridin, as a novel anti-obesity compound. Animal studies and phase I human trials have shown that HSG4112 improves energy consumption, normalises weight, and is safe and drug-
Externí odkaz:
https://doaj.org/article/88d4e45a96b844b19819f5ef6b404e96
Autor:
Ravishankar Chandrasekaran, Carolyn R. Morris, Isabella M. Butzirus, Zoe F. Mark, Amit Kumar, Dhemerson Souza De Lima, Nirav Daphtary, Minara Aliyeva, Matthew E. Poynter, Vikas Anathy, Anne E. Dixon
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Obesity is a risk factor for severe influenza, and asthma exacerbations caused by respiratory viral infections. We investigated mechanisms that increase the severity of airway disease related to influenza in obesity using cells derived from obese and
Externí odkaz:
https://doaj.org/article/102c1f06ace041a5879ef9e87c8fd3d8