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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThis study aimed to investigate the role of Nicotinamide N-methyltransferase (NNMT) in the drug sensitivity of non-small cell lung cancer (NSCLC) cells, with a focus on its impact on autophagy and resistance to the chemotherapeutic agent
Externí odkaz:
https://doaj.org/article/1c9b672d67b14a24897109b35e39a1b4
Autor:
Marlaine Michel Boukandou Mounanga, Annais Mezui, Ludovic Mewono, Jean Bertrand Mogangué, Sophie Aboughe Angone
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Gabon faced COVID-19 with more than 49,000 individuals tested positive and 307 recorded fatalities since the first reported case in 2020. A popular hypothesis is that the low rate of cases and deaths in the country was attributed to the u
Externí odkaz:
https://doaj.org/article/33d0954a1b754a8a850e8a8d4f8a64b8
Autor:
Daniela Impellizzeri, Marika Cordaro, Michela Campolo, Enrico Gugliandolo, Emanuela Esposito, Filippo Benedetto, Salvatore Cuzzocrea, Michele Navarra
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/10cedd7d2fb0462880299907ac217474
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Heterotopic ossification of the elbow (HOE) is a complicated pathologic process characterized by extra bone formation in the elbow. Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells into osteobl
Externí odkaz:
https://doaj.org/article/3baaf8707b644cc1a0b076a8e4f1464d
Autor:
Priyanka Soni, Navneet Ammal Kaidery, Sudarshana M. Sharma, Irina Gazaryan, Sergey V. Nikulin, Dmitry M. Hushpulian, Bobby Thomas
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Neurodegenerative diseases represent a pressing global health challenge, and the identification of novel mechanisms underlying their pathogenesis is of utmost importance. Ferroptosis, a non-apoptotic form of regulated cell death characterized by iron
Externí odkaz:
https://doaj.org/article/f038aea9e6284c14be3570e61d8fc184
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Aims: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are employed extensively in the management of type 2 diabetes and obesity. However, there is a paucity of real-world data on their safety and tolerability for metabolic and nutritional adver
Externí odkaz:
https://doaj.org/article/6a908ecef7f24a8887881d6745754ea5
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cyclophilins (Cyps), characterized as peptidyl-prolyl cis-trans isomerases (PPIases), are highly conserved and ubiquitous, playing a crucial role in protein folding and cellular signaling. This review summarizes the biochemical pathways mediated by C
Externí odkaz:
https://doaj.org/article/0ba02b5046a340a08ec726aee8d3084b
Autor:
Jing Yang, Lei Chen, Shan-Shan Zhao, Chuang Du, Yi-Zhe Fan, Hui-Xin Liu, Yongchun Li, Yong-Zhi Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe beneficial effects of fibroblast growth factor 21 (FGF21) and sodium butyrate (NaB) on protection against cholestasis-induced liver fibrosis are not well known. This study aimed to explore the effects of FGF21 and NaB on bile duct ligat
Externí odkaz:
https://doaj.org/article/ee0be7ebbd2c4f7da91a31cf3528f35d
Autor:
Lirong Wu, Jieyi Wang, Jing Lei, Kun Ge, Chun Qu, Jiajian Liu, Fengjie Huang, Dongnan Sun, Xiaowen Chao, Tianlu Chen, Aihua Zhao, Wei Jia, Xiaojiao Zheng, Guoxiang Xie
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Porcine bile powder (PBP) is a traditional Chinese medicine that has been used for centuries in various therapeutic applications. However, PBP has not previously undergone comprehensive component analysis and not been evaluated for safety
Externí odkaz:
https://doaj.org/article/ee4abf68de1941be8b0924e1a7c9465f
Autor:
Libo Wang, Fei Lin, Youli Liu, Wei Li, Qingjie Ding, Xulei Duan, Lin Yang, Zhengyu Bai, Min Zhang, Yuming Guo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Pulmonary fibrosis (PF) is a fatal interstitial lung disease associated with declining pulmonary function but currently with few effective drugs. Cellular senescence has been implicated in the pathogenesis of PF and could be a potential therapeutic t
Externí odkaz:
https://doaj.org/article/1805bab91acc438ba5514d72dcb9e47f