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Autor:
Yanxin Liu, Dongxu Wang, Yanhong Luan, Boqiang Tao, Qirong Li, Qiang Feng, Hengzong Zhou, Jianfeng Mu, Jinhai Yu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Intestinal organoids are a three-dimensional cell culture model derived from colon or pluripotent stem cells. Intestinal organoids constructed in vitro strongly mimic the colon epithelium in cell composition, tissue architecture, and specific functio
Externí odkaz:
https://doaj.org/article/8c5a0f00f72e4a3390d303228c1785a3
Autor:
Jian He, Guojun Li, Yu Wu, Tong Zhang, Mingjiang Yao, Mingxuan Zang, Jianhua Zou, Jinjie Song, Liusheng Li, Qian Chen, Guang Cao, Linlin Cai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveJianPiHuaTan Formula (JPHTF), a traditional Chinese medicine (TCM), has been utilized as an adjunctive therapy for colorectal cancer (CRC). The study aims to evaluate the potential clinical benefits of JPHTF and its effectiveness in inhibiti
Externí odkaz:
https://doaj.org/article/9a54d0ca390b45a6aa8093f2d4f79e0a
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionColorectal cancer is a highly aggressive and metastatic cancer with inadequate clinical outcomes. Given the crucial role of histamine and histamine receptors in colorectal carcinogenesis, this study aimed at exploring the anticancer effec
Externí odkaz:
https://doaj.org/article/ca77d3b67aea453dbfea2d48272b0f78
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Ginsenosides, the primary bioactive ingredients derived from the root of Panax ginseng, are eagerly in demand for tumor patients as a complementary and alternative drug. Ginsenosides have increasingly become a “hot topic” in recent years due to t
Externí odkaz:
https://doaj.org/article/0ab29ae529da45cd8cfbcec139c964c0
Autor:
Adriana Ochoa-Sanchez, Padmavati Sahare, Surajit Pathak, Antara Banerjee, Miriam Estevez, Asim K. Duttaroy, Gabriel Luna-Bárcenas, Sujay Paul
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Colorectal cancer (CRC) remains a significant global health concern, being the third most diagnosed cancer in men and the second most diagnosed cancer in women, with alarming mortality rates. Natural phytochemicals have gained prominence among variou
Externí odkaz:
https://doaj.org/article/4fb9a53d58f1464b842979b0fc8e5209
Autor:
Yiping Zhang, Jun Xie
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed cancer and the second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such as delayed diagnosis, multidrug
Externí odkaz:
https://doaj.org/article/4144c71870014760bcbc782e1e3a865d
Autor:
Xiao-Peng Li, Liang-Qi Cao, Ze-Zhong Yu, Ke He, Peng-Bo Ding, Ji-Sheng Li, Yi-Yao Shan, Yu-Bin Su, Zhong-Min Yuan, Zhi Shi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Colorectal cancer is a common malignant tumor with high mortality, for which chemotherapy resistance is one of the main reasons. The high expression of ABCG2 in the cancer cells and expulsion of anticancer drugs directly cause multidrug resistance (M
Externí odkaz:
https://doaj.org/article/ae7db782faa442689f55607797dbbf6b
Autor:
Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
During the past half-century, although numerous interventions for obesity have arisen, the condition’s prevalence has relentlessly escalated annually. Obesity represents a substantial public health challenge, especially due to its robust correlatio
Externí odkaz:
https://doaj.org/article/1a0ef4cffe9b4113afa5f2271f4e4f0d
Autor:
Lihua Chen, Shaojian Chen, Yachen Li, Yi Qiu, Xiaojing Chen, Yuze Wu, Xian Deng, Mingliang Chen, Chunxiao Wang, Zhongshi Hong, Chengzhi Qiu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear.MethodsWe performed an
Externí odkaz:
https://doaj.org/article/910ee0578c2a41cca9a7b546fe70680e
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Colorectal cancer (CRC) is a significant global health burden, with high morbidity and mortality rates. It is often diagnosed at middle to advanced stage, affecting approximately 35% of patients at the time of diagnosis. Currently, chemotherapy has b
Externí odkaz:
https://doaj.org/article/10a11c762dd04f22b27a9faff00d1c7c