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Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Colorectal cancer (CRC) is the second most lethal malignancy worldwide. The high mortality rate of CRC is largely due to cancer metastasis. Recently, suppressing epithelial-to-mesenchymal transition (EMT) has been considered a promising strategy for
Externí odkaz:
https://doaj.org/article/696fec25c1aa450d8434538953fa459d
Autor:
Huiling Liang, Yanju Li, Feiqing Wang, Jianing Zhao, Xu Yang, Dan Wu, Chike Zhang, Yanqing Liu, Jie Huang, Min Su, Zhixu He, Yang Liu, Jishi Wang, Dongxin Tang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Asparagus (ASP) is a well-known traditional Chinese medicine with nourishing, moistening, fire-clearing, cough-suppressing, and intestinal effects. In addition, it exerts anti-inflammatory, antioxidant, anti-aging, immunity-enhancing, and anti-tumor
Externí odkaz:
https://doaj.org/article/ded9dbf257e74b4090c2dcb4a68751e8
Autor:
Kangjia Luo, Yanni Song, Zilong Guan, Suwen Ou, Jinhua Ye, Songlin Ran, Hufei Wang, Yangbao Tao, Zijian Gong, Tianyi Ma, Yinghu Jin, Rui Huang, Feng Gao, Shan Yu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: KRAS mutation, one of the most important biological processes in colorectal cancer, leads to poor prognosis in patients. Although studies on KRAS have concentrated for a long time, there are currently no ideal drugs against KRAS mutations
Externí odkaz:
https://doaj.org/article/33de1e8b99424281a47c864fc3238026
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The potential role of tadalafil, a PDE5 inhibitor, in anticancer activity and prolonged survival has been proposed. However, the systematic effects of tadalafil in colorectal cancer were not fully understood. In this study, we assessed the anti-tumor
Externí odkaz:
https://doaj.org/article/f1af91732fff40d185ec7e9b95b04b94
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Colorectal cancer (CRC) is a major public health problem on a global scale by virtue of its relatively high incidence. The transition of tumor cells from an epithelial to a mesenchymal-like phenotype, so-called epithelial-to-mesenchymal transition (E
Externí odkaz:
https://doaj.org/article/9ce32875c0d44b109bfb06d83582d580
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Accumulating evidence indicates that RNA methylation, as the most common modification of mRNA, is of great significance in tumor progression and metastasis. Colorectal cancer is a common malignant tumor of the digestive system that seriously affects
Externí odkaz:
https://doaj.org/article/8d972c7919df4c28abb14808d4b7b1bd
Autor:
Junkui Li, Peili Zhu, Yifei Chen, Shiqing Zhang, Zhu Zhang, Zhang Zhang, Ying Wang, Xiaoli Jiang, Kaili Lin, Wei Wu, Zhixian Mo, Stephen Cho Wing Sze, Ken Kin Lam Yung
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Colorectal cancer (CRC) is an aggressive cancer. Isoalantolactone (IATL) has been reported to exert cytotoxicity against various cancer cells, but not CRC. In this study, we explored the anti-CRC effects and mechanism of action of IATL in vitro and i
Externí odkaz:
https://doaj.org/article/d9f5cb620b424cb28c9cd1eac38d1a26
Autor:
Bin Chen, Linguangjin Wu, Xiaoxia Tang, Ting Wang, Shuyun Wang, Hongjie Yu, Guangsheng Wan, Manli Xie, Ruijuan Zhang, Haijuan Xiao, Wanli Deng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Quercetin can significantly inhibit the progression of colorectal cancer (CRC). However, its specific mechanism remains largely unclear. In this study, we aimed to explore the correlation among quercetin, tumour-associated macrophages (TAMs) and circ
Externí odkaz:
https://doaj.org/article/86ffb1001d5346438ea168b96e2d1dd8
Autor:
Lanzhou Li, Chenfei Zhao, Fange Kong, Yi-Cong Li, Chunxia Wang, Shanshan Chen, Hor-Yue Tan, Yang Liu, Di Wang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Calf thymus polypeptide (CTP), with a molecular mass of
Externí odkaz:
https://doaj.org/article/0060434f707f48278ccc6a8124dad54d
Autor:
Mengmeng Cai, Ya Xiao, Zhibing Lin, Jinmiao Lu, Xiaoyu Wang, Sajid Ur Rahman, Shilan Zhu, Xiaoyu Chen, Jialin Gu, Yuzhu Ma, Zhaoguo Chen, Jiege Huo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Purpose: This study aimed to investigate the relationship between gut microbiota (GM) and serum metabolism using antineoplastic Fufangchangtai (FFCT) as the model prescription in the treatment of colorectal cancer (CRC).Methods: Tumor-bearing mice an
Externí odkaz:
https://doaj.org/article/76a3210644fb4e9d8ac27c311cc48875