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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Clobenpropit is a histamine H3 receptor antagonist and has developed as a potential therapeutic drug due to its ability to inhibit CXCR4, a chemokine receptor involved in autoimmune diseases and cancer pathogenesis. The CXCL12/CXCR4 axis involves sev
Externí odkaz:
https://doaj.org/article/64b4ca7ba62b444288efd366d8652684
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
This review focuses on the expression and function of voltage-gated sodium channel subtype NaV1.7 in various cancers and explores its impact on the metastasis driving cell functions such as proliferation, migration, and invasiveness. An overview of i
Externí odkaz:
https://doaj.org/article/38393a0ff2444ac094ff1c743b83f820
Autor:
Bruno Raphael Ribeiro Cavalcante, Raíza Dias Freitas, Leonardo de Oliveira Siquara da Rocha, Roberto de Souza Batista Dos Santos, Bruno Solano de Freitas Souza, Pablo Ivan Pereira Ramos, Gisele Vieira Rocha, Clarissa Araújo Gurgel Rocha
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Cancer refers to a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body. Due to its complexity, it has been hard to find an ideal medicine to treat all cancer types, although there is an ur
Externí odkaz:
https://doaj.org/article/55e4871432c743eeb324c388c92dbb7b
Autor:
Ziying Zhou, Yi Nan, Xiangyang Li, Ping Ma, Yuhua Du, Guoqing Chen, Na Ning, Shicong Huang, Qian Gu, Weiqiang Li, Ling Yuan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Over the past few years, there has been a gradual increase in the incidence of cancer, affecting individuals at younger ages. With its refractory nature and substantial fatality rate, cancer presents a notable peril to human existence and wellbeing.
Externí odkaz:
https://doaj.org/article/99059456f8ea4e17847802cb0b713640
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Around 1 in 7 men will be diagnosed with prostate cancer during their lifetime. Many strides have been made in the understanding and treatment of this malignancy over the years, however, despite this; treatment resistance and disease progression rema
Externí odkaz:
https://doaj.org/article/f662e40d5a974d799a015dee92464ecc
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Maintaining the structural integrity of genomic chromosomal DNA is an essential role of cellular life and requires two important biological mechanisms: the DNA damage response (DDR) mechanism and telomere protection mechanism at chromosome ends. Beca
Externí odkaz:
https://doaj.org/article/1a159fc4f47f4bf0bb23db8b5f6cac01
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe impact of renin-angiotensin system inhibitors (RASIs) on the outcome of hypertensive cancer patients undergoing immune checkpoint inhibitor (ICIs) therapy remains ambiguous. This investigation sought to elucidate the consequences of RAS
Externí odkaz:
https://doaj.org/article/abf5ef6a332a435eb188c5245ceeffd3
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/ab9dec6b8cd04074a41cce22e032c42d
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Combination therapies can enhance the sensitivity of cancer to drugs, lower drug doses, and reduce side effects in cancer treatment. However, differences in the physicochemical properties and pharmacokinetics of different therapeutic agents limit the
Externí odkaz:
https://doaj.org/article/1b91dfd73da94fc6a975ad4020590c35
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cancer targeted therapy is essential to minimize damage to normal cells and improve treatment outcomes. The elevated activity of Cystathionine beta-synthase (CBS), an enzyme responsible for producing endogenous hydrogen sulfide (H2S), plays a signifi
Externí odkaz:
https://doaj.org/article/7a7ba45629954e409caceacaffd8edf9