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Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Ferroptosis is an emerging mode of programmed cell death fueled by iron buildup and lipid peroxidation. Recent evidence points to the function of ferroptosis in the aetiology and development of cancer and other disorders. Consequently, harnessing iro
Externí odkaz:
https://doaj.org/article/e7a70c265a334d6d95f0312b9f0aeb61
Autor:
Marco Cozzolino, Gyorgy Panyi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background:The unique microenvironment in tumors inhibits the normal functioning of tumor-infiltrating lymphocytes, leading to immune evasion and cancer progression. Over-activation of KCa3.1 using positive modulators has been proposed to rescue the
Externí odkaz:
https://doaj.org/article/9efa757e6e034ca88d9dfd3d04448d90
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cancer is the main cause of death in the world. There are several therapies that are in practice for cancer cure including radiotherapy, chemotherapy, and surgery. Among the chemotherapies, natural products are considered comparable safe, easily avai
Externí odkaz:
https://doaj.org/article/99c2a0afb234420dba5b7a85ead49c46
Autor:
Aqsa Khan, Asifa Khan, Mohammad Aasif Khan, Zoya Malik, Sheersh Massey, Rabea Parveen, Saad Mustafa, Anas Shamsi, Syed A. Husain
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
For centuries, plants have been serving as sources of potential therapeutic agents. In recent years, there has been a growing interest in investigating the effects of plant-derived compounds on epigenetic processes, a novel and captivating Frontier i
Externí odkaz:
https://doaj.org/article/98cccb3b8ea24f2dbbac11fe30ce1272
Autor:
Jia-Yu Zou, Qi-Lei Chen, Xiao-Ci Luo, Davaadagva Damdinjav, Usama Ramadan Abdelmohsen, Hong-Yan Li, Tungalag Battulga, Hu-Biao Chen, Yu-Qing Wang, Jian-Ye Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor
Externí odkaz:
https://doaj.org/article/01497fce427c4255a11c1df65713be01
Autor:
Chou-Yi Hsu, Sadegh Rajabi, Maryam Hamzeloo-Moghadam, Abhinav Kumar, Marc Maresca, Pallavi Ghildiyal
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Apoptosis is a programmed cell death comprising two signaling cascades including the intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy response of different cancer types, making it an effective target for tre
Externí odkaz:
https://doaj.org/article/c80c3bc1770f4568b1383a3e40abc91a
Autor:
Nan Zhang, Gui-Yuan Song, Qing-Hua Yu, Xin-Ming Fan, Wen-Shuo Zhang, Yong-Jian Hu, Tian-Zhu Chao, Yao-Yao Wu, Shu-Yan Duan, Fei Wang, Rui-Peng Du, Ping Xu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Previous studies have documented important roles for microRNA-147 (miR-147) in inflammation, radiation-induced injury, cancer, and a range of other diseases. Murine lungs exhibit high levels of miRNA, mRNA, and lncRNA expression. However,
Externí odkaz:
https://doaj.org/article/ba0cc6788e5c4cd38ffd6286a20b15ef
Autor:
Endika Martín-Encinas, María Fuertes, Samuel Delgado-Hernández, Fernando García-Tellado, David Tejedor, Concepción Alonso
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
This work explores the biological evaluation of novel cyanomethyl vinyl ether derivatives as antiproliferative agents. Tubulin, crucial to microtubule structure and function, is a target for cancer therapies. In vitro cytotoxicity assessments reveale
Externí odkaz:
https://doaj.org/article/849db96aafa443d2b093fc7f1ece9c03
Autor:
Pantha Prodip Ray, Mohammad Ashraful Islam, Mohammad Safiqul Islam, Aixia Han, Peiwu Geng, Md. Abdul Aziz, Abdullah Al Mamun
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a
Externí odkaz:
https://doaj.org/article/c10e762327d04366a9a46f83946c764e
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Autophagy is a conserved, cellular self-degradation system that is essential for maintaining intracellular homeostasis. Increasing evidence suggests that autophagy plays an important dual regulatory role in the development of many human diseases, suc
Externí odkaz:
https://doaj.org/article/b865ff2668a5488d96f0b891e7515943