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Autor:
Pascal Büttiker, Simon Weissenberger, Tobias Esch, Martin Anders, Jiri Raboch, Radek Ptacek, Richard M. Kream, George B. Stefano
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Mitochondria are complex endosymbionts that evolved from primordial purple nonsulfur bacteria. The incorporation of bacteria-derived mitochondria facilitates a more efficient and effective production of energy than what could be achieved based on pre
Externí odkaz:
https://doaj.org/article/8ed7435e0f6348b4ad736471e8be17cc
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Epilepsy and depression are both serious and potentially disabling conditions which often coexist—bidirectional relationship between the two disorders has been observed. Comorbidity between depression and epilepsy can be attributed to: underlying c
Externí odkaz:
https://doaj.org/article/4f5b346edf2649bf86875888d8ef73c1
Autor:
Xiuqing Zhu, Jinqing Hu, Shuhua Deng, Yaqian Tan, Chang Qiu, Ming Zhang, Xiaojia Ni, Haoyang Lu, Zhanzhang Wang, Lu Li, Yayan Luo, Shanqing Huang, Tao Xiao, Shujing Liu, Xiaolin Li, Dewei Shang, Yuguan Wen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-infla
Externí odkaz:
https://doaj.org/article/d2071d6fddcb4776b19d1ce381e27f95
Autor:
Norbert Müller
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Intercellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein that is overexpressed in many pathological states. Although, like many other immune molecules, ICAM-1 plays only a limited role in the abundant concert of the immune response,
Externí odkaz:
https://doaj.org/article/7af8782447c84c05ba2f5b8ef55397fb
Autor:
Anindya Bhattacharya
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction. Emerging data has generated scientific interest and excitement around targeting
Externí odkaz:
https://doaj.org/article/e7062608e938493d90d93be7ec6d6219