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Autor:
Haiyan Luo, Yao Li, Honghu Song, Kui Zhao, Wenlin Li, Hailan Hong, Yun-Ting Wang, Luming Qi, Yang Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Vascular smooth muscle cells (VSMCs) are integral to the pathophysiology of cardiovascular diseases (CVDs). Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, plays a crucial role in epigenetic regulation of VSMCs gene expression. Emerg
Externí odkaz:
https://doaj.org/article/2455ab5eadda4ce3a8a500521b0c86c3
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promot
Externí odkaz:
https://doaj.org/article/61957186004b4a3997b884817e809623
Autor:
Shouyi Liu, Bo Zhang, Jingqun Zhou, Jianfeng Lv, Jinxia Zhang, Xiangyan Li, Weihua Yang, Yuanlin Guo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The clinical efficacy of adrenergic β-receptor (β-AR) blockers in significantly stabilizing atherosclerotic plaques has been extensively supported by evidence-based medical research; however, the underlying mechanism remains unclear. Recent finding
Externí odkaz:
https://doaj.org/article/8d01a5979ca74d83b6589e667b35cb22
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of cardiovascular mortality and is increasingly prevalent in our population. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) can safely and effectively lower glucose levels while
Externí odkaz:
https://doaj.org/article/3555eae17c6a4774b69bffa5a0871207
Autor:
Xiaohong Qin, Rui Ding, Haoran Lu, Wenfei Zhang, Shanshan Wei, Baowei Ji, Rongxin Geng, Liquan Wu, Zhibiao Chen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Objective:Bioinformatics methods were applied to investigate the pivotal genes and regulatory networks associated with atherosclerotic carotid artery stenosis (ACAS) and provide new insights for the treatment of this disease.Methods:The study utilize
Externí odkaz:
https://doaj.org/article/19c326d42ede41e49b6fd75147f79aa3
Autor:
Lin Zhou, Hongyu Zhang, Shuyi Wang, Hong Zhao, Yongnan Li, Juqian Han, Hongxu Zhang, Xiaoyuan Li, Zhengyi Qu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Ischemic stroke, the most prevalent and serious manifestation of cerebrovascular disease, is the main cause of neurological problems that require hospitalization, resulting in disability and death worldwide. Currently, clinical practice focuses on th
Externí odkaz:
https://doaj.org/article/ef8c0dbb0e16478b9ebe4286e7a49c60
Autor:
Ana Paula Cestari, Francielly Mourão Gasparotto, Cândida Aparecida Leite Kassuya, Tauany Milan Ribeiro Lacerda, Guilherme Donadel, Catia Sari Moura, Daniela Boleta Ceranto, Ezilda Jacomassi, Odair Alberton, Salviano Belletini Tramontini, Luana Ale Bertoncello, Arquimedes Gasparotto Junior, Emerson Luiz Botelho Lourenço
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction:Plinia cauliflora [Mart.] Kausel (Myrtaceae), popularly known as “jabuticaba,” is a fruit species native to Brazil. Despite extensive widespread usage, its antiatherosclerotic properties' impact remains unknown. Thus, the present stu
Externí odkaz:
https://doaj.org/article/302a925808bd4bb6b3f27d8e6075bcac
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Tanshinone IIA (Tan IIA) is a fat-soluble compound extracted from Salvia miltiorrhiza, which has a protective effect against atherosclerosis (AS). Tan IIA can inhibit oxidative stress and inflammatory damage of vascular endothelial cells (VECs) and i
Externí odkaz:
https://doaj.org/article/cc886abce63347a3ad5904590b0aa675
Autor:
Liuping Chen, Huiqi Chen, Sien Guo, Zhijun Chen, Haifeng Yang, Yanjiao Liu, Xiaoling Chen, Xinming Chen, Tingting Du, Xinyao Long, Jiaxiong Zhao, Mingli Guo, Tianfeng Lao, DongHui Huang, Lei Wang, Jing Chen, Chunping Liu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Psoriasis (PSO) is a common skin disease affecting approximately 1%–3% of the population, and the incidence rate is increasing yearly. PSO is associated with a dramatically increased risk of cardiovascular disease, the most common of which is ather
Externí odkaz:
https://doaj.org/article/2cf8df9b81524f6781a7421afbd9cd95
Autor:
Junping Li, Changping Li, Zhaoqi Huang, Chunling Huang, Juanzhang Liu, Tao Wu, Shuwan Xu, Peibiao Mai, Dengfeng Geng, Shuxian Zhou, Kun Zhang, Zhaoyu Liu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
SGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay the progression of atherosclerosis. However, its role in atherosclerotic calcification remains unclear. In this research, ApoE−/
Externí odkaz:
https://doaj.org/article/702a55825c684cd4be2c4bfcbe06934e