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Autor:
Lin Zhao, Yi Sun, Xiaoran Yang, Ling Tian, Lize Li, Fangfang Wang, Xiaoye Niu, Lei Diao, Haiyan Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cardiotoxicity and QT interval prolongation have been a common cause of withdrawal of drugs from the market. FCN-437c is an oral, second-generation, potent, and selective CDK4/6 inhibitor for the treatment of patients with HR+/HER2- metastatic breast
Externí odkaz:
https://doaj.org/article/f2cebee37b224c779304de53b04a4ef2
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThis study assessed the relationship between β-blockers treatment and in-hospital mortality among individuals diagnosed with heart failure (HF).MethodsA retrospective cohort study was carried out on 9,968 HF patients sourced from the Med
Externí odkaz:
https://doaj.org/article/305f6443fab3459a96b9cdce2a8dc617
Autor:
Greta Cascetta, Giorgia Colombo, Gianmarco Eremita, Joe G. N. Garcia, Marco Vincenzo Lenti, Antonio Di Sabatino, Cristina Travelli
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mu
Externí odkaz:
https://doaj.org/article/3030a441c3e4473898fb3dc8d64db423
Autor:
Xiao-Meng Sun, Xin Wu, Meng-Guang Wei, Li-Zeng Zhu, Wen-hui Wu, Xin-Yue Zhou, Lian-Wen Qi, Qun Liu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Elevated glucagon levels are a characteristic feature of type 2 diabetes. This abnormal increase in glucagon can lead to an accelerated rate of gluconeogenesis. Glucagon also stimulates hepatic metabolism of amino acids, particularly pr
Externí odkaz:
https://doaj.org/article/bcea602d6555461d845a44a1ac46f4cb
Autor:
Xiaoyan Tian, Kunling Fu, Xuemin Huang, Haiyan Zou, Nianmei Shi, Jiayang Li, Yuxiang Bao, Sisi He, Junyuan Lv
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Ferroptosis represents a distinct form of cell death that is not associated with necrosis, autophagy, apoptosis, or pyroptosis. It is characterised by intracellular iron-dependent lipid peroxidation. The current literature indicates that a number of
Externí odkaz:
https://doaj.org/article/7d89b0c3983d4955a88eb894bb36debb
Autor:
Yiwen Wang, Xuna Liu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
PurposeSacubitril/valsartan is extensively used in heart failure; however, there are few long-term safety studies of it in a wide range of populations. The aim of this study was to evaluate sacubitril/valsartan-induced adverse events (AEs) through da
Externí odkaz:
https://doaj.org/article/a6ca70cb63cd47ac9a3303f32c58c19c
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundTralokinumab, a humanized monoclonal antibody targeting interleukin-13, has been primarily used for the treatment of moderate-to-severe atopic dermatitis. Given its extensive use in clinical practice, understanding its safety profile in the
Externí odkaz:
https://doaj.org/article/07d88359576d4bb08464f1b3a87f8b3f
Autor:
Karolina Kłoda, Mateusz Babicki, Aleksander Biesiada, Małgorzata Gałązka-Sobotka, Iwona Kowalska-Bobko, Agnieszka Mastalerz-Migas
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: In Poland, the area of self-medication requires scientific and organizational evaluation. So far, no solutions sanctioning self-medication have been introduced. Therefore, the aim of this study was to recognize and analyze the practical
Externí odkaz:
https://doaj.org/article/f92603ba3a04432d80c692120d9d59b5
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
There is substantial evidence from clinical and preclinical studies suggesting an association between metformin use and a reduced risk of cancer. However, the effects of metformin use on cancers have not yet been subjected to bibliometric analysis. T
Externí odkaz:
https://doaj.org/article/6bcc94b9692b46c199ebbf78a0e4e1a1
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundMethyltransferase-like 3 (METTL3), a component of the N6-methyladenosine (m6A) methyltransferase family, exhibits significant expression in HEI-OC1 cells and cochlear explants. Aminoglycoside antibiotics, known for their ototoxic potential,
Externí odkaz:
https://doaj.org/article/0bb8084fb38d4a4eb35199fe63c32a2d