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Autor:
Jinfeng Chen, An Zhang, Anzheng Nie, Xiaoxiao Zuo, Lei Zhang, Yuxue Jiao, Lulu Wang, Yang Yang, Kun Liu, Xinli Xue, Yuanyuan Zhuang, Yansha Meng, Jing-Hua Yang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background:Stephania tetrandra has been used for treating rheumatic diseases for thousands of years in rural areas of China. Several studies have found that tetrandrine and fangchinoline can inactivate the PI3K/Akt signaling pathway by reducing the e
Externí odkaz:
https://doaj.org/article/16a611a7bf8b49a4a5b214d8dd2e9ce3
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Therapeutic antibodies (Abs) have been anticipated as promising alternatives to conventional treatments such as topical minoxidil and oral finasteride for androgenetic alopecia (AGA). Due to the high molecular weight of typical Abs, the half-life of
Externí odkaz:
https://doaj.org/article/bba5365674bc4ec99d89fa1a6ba7d62f
Autor:
Xia Lei, Jiapeng Wang, Kun Zuo, Tianli Xia, Jinfeng Zhang, Xiangyue Xu, Qing Liu, Xiaoliang Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The dried root and rhizome of Alpinia officinarum Hance (A. officinarum) have been widely used in traditional Chinese medicine for thousands of years to alleviate pain, promote digestion, warm the stomach, and disperse cold. This review aims to compr
Externí odkaz:
https://doaj.org/article/6e4616eaf2c74291af7255230b54bd23
Autor:
Shike Lou, Xiaoyin Wang, Fei Yuan, Gangde Zhao, Mingyang Feng, Yezhou Ding, Lanyi Lin, Kehui Liu, Xiaolin Wang, Wanqing Chi, Hui Wang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
This study investigated the potential of immune checkpoint inhibitors (ICIs) combined with chemotherapy as a promising treatment approach for malignancies. This report focuses on a patient with drug-induced liver injury (DILI) following the administr
Externí odkaz:
https://doaj.org/article/a1cc9b01e6e44e138b308e962bed9d49
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThis study aimed to identify novel therapeutic targets for primary open-angle glaucoma (POAG).MethodsThe summary-data-based Mendelian randomization (SMR) method was used to evaluate the genetic association between plasma proteins and POAG.
Externí odkaz:
https://doaj.org/article/d8bdbd6daa31482691a9bc735e331e26
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The physiological effects of glucagon-like peptide-1 (GLP-1) are mainly centered on its ability to decrease blood glucose levels and facilitate satiety. Additional physiological functions have been identified by means of GLP-1 agonists such as exenat
Externí odkaz:
https://doaj.org/article/f84f82cb398e4425811707b5bcfa5714
Autor:
Wubetu Yihunie Belay, Melese Getachew, Bantayehu Addis Tegegne, Zigale Hibstu Teffera, Abebe Dagne, Tirsit Ketsela Zeleke, Rahel Belete Abebe, Abebaw Abie Gedif, Abebe Fenta, Getasew Yirdaw, Adane Tilahun, Yibeltal Aschale
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability to effectively treat bacterial infections. This review aims to provide a comprehensive overview of the types and mechanisms of antibacte
Externí odkaz:
https://doaj.org/article/f35ddf6def9341dc94be223806eeb913
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aimPathological changes in the central nervous system (CNS) begin before the clinical symptoms of Alzheimer’s Disease (AD) manifest, with the hippocampus being one of the first affected structures. Current treatments fail to alter AD
Externí odkaz:
https://doaj.org/article/4faab178320d40a68716fd3c2013495d
Autor:
Zimengwei Ye, Yi Zhao, Yanjing Cui, Bingrui Xu, Fan Wang, Dandan Zhao, Guangtong Dong, Zhufeng Wang, Rui Wu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Obesity, a global epidemic, is caused by an imbalance between energy intake and expenditure. The induction of white adipose browning to increase heat production has emerged as a potential effective strategy to address obesity. Ling-gui-
Externí odkaz:
https://doaj.org/article/0b257bc08313480ebf0fe01096a022f4
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundsUlcerative colitis (UC) is a form of chronic inflammatory bowel disease, and UC diagnosis rates continue to rise throughout the globe. The research and development of new drugs for the treatment of UC are urgent, and natural compounds are
Externí odkaz:
https://doaj.org/article/0f615d8170cb4db7b0f1d5b9c5fc5aa6