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Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 242 (2024)
Autophagy is an evolutionarily conserved process in which intracellular macromolecules are degraded in a lysosomal-dependent manner. It is central to cellular energy homeostasis and to quality control of intracellular components. A decline in autopha
Externí odkaz:
https://doaj.org/article/23d2722e6ecb45e0aa811d702fba6906
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 260 (2024)
Retinal degeneration (RD) is a group of chronic blinding diseases characterised by progressive retinal cell death. As the disease progresses, vision deteriorates due to retinal cell death and impaired retinal integrity, eventually leading to complete
Externí odkaz:
https://doaj.org/article/42c37f53f78844f1a3b9960e85cdd455
Autor:
Xu Zhao, Zhengyang Hou, Yaxin Zhang, Daoqin Mao, Zhenfang Yan, Shunyu Yang, Jingying Xie, Ruofei Feng
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 273 (2024)
Background: Understanding the mechanisms through which interferon (IFN) signaling is negatively regulated is crucial for preserving the equilibrium of innate immune reactions, as the innate immune system functions, such as the original barrier, comba
Externí odkaz:
https://doaj.org/article/6ffc49143f8946119615a7922513c50e
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 274 (2024)
Background: Diabetic cardiomyopathy (DCM) is an important cause of heart failure in diabetic patients. The aim of this study was to investigate the pathogenesis of DCM and to identify potential therapeutic targets. Methods: A mouse model of type 1 DC
Externí odkaz:
https://doaj.org/article/a472a678af9748f3a7cb71ce19e467ba
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 231 (2024)
The inhibitors of mammalian target of rapapmycin (mTOR), everolimus, temsirolimus and rapamycin, have a wide range of clinical utility; however, as is inevitably the case with other chemotherapeutic agents, resistance development constrains their eff
Externí odkaz:
https://doaj.org/article/26f363ffd1e944e3bf406f4ef7ab99de
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 212 (2024)
Background: Gastric cancer (GC) is a leading cause of cancer-associated death worldwide. Its molecular mechanisms, especially concerning autophagy and various signaling pathways, are not fully understood. Fatty Acid Binding Protein 6 (FABP6) and RE1
Externí odkaz:
https://doaj.org/article/b47a57d7ada942b18291968fedc9c9c5
Autor:
Jing Nie, Hongbin Qiu
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 222 (2024)
Background: Persistent hyperuricemia can lead to the generation and deposition of monosodium urate (MSU) crystals. This can trigger gouty arthritis (GA), which in turn induces inflammation. Activation of the Nod-like receptor pyrin domain containing
Externí odkaz:
https://doaj.org/article/9621055ba88e4ab497cdbd5777e350a8
Autor:
Huiyuan Qin, Bingyu Zheng, Zhiqiao Lin, Yumeng Ji, Cheng Wang, Huayuan Zhu, Chang Cui, Zidun Wang, Minglong Chen
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 5, p 201 (2024)
Background: Ibrutinib could increase the risk of atrial fibrillation (AF) in chronic lymphocytic leukemia (CLL) patients. However, the precise mechanism underlying ibrutinib-induced AF remains incompletely elucidated. Methods: We investigated the pro
Externí odkaz:
https://doaj.org/article/90f2ee7906b74bde9f77326e942a882a
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 2, p 70 (2024)
Background: The number of older people in the world is increasing year by year; studies have shown that more than 90% of cardiovascular disease occurs in the older people population, indicating that aging is one of the major risks involved in the dev
Externí odkaz:
https://doaj.org/article/b1c97c2229324fe7934e5dd960d9840a
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 15 (2024)
Objective: The present study aims to investigate the effect of Huaier on oxaliplatin (OXA) resistance in HCT-8 colorectal cancer (CRC) cells. Methods: Oxaliplatin-resistant HCT-8/L CRC cells were used. The Cell Counting Kit-8, western blotting, quant
Externí odkaz:
https://doaj.org/article/1f14059a407a413d97f376940cc2802d